ADC Cytotoxin

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ADCs Cytotoxin
Early ADCs relied on drugs that were already
approved for use as small molecules, such
as vinblastine and doxorubicin, and suffered from
lack of potency and low clinical activities.
Substantially more potent drugs that were too
toxic to use in an untargeted manner have been
more promising as ADCs. These include
auristatins, maytansines, and calicheamicins.
Auristatins and maytasines both exert their
cytotoxic effects by binding to tubulin, causing
G2/M cell cycle arrest, and subsequently leading
to apoptosis.