Data Processing and Interpretation in Creative Biostructure

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Data Processing and Interpretation in Creative
Biostructure
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• Creative Biostructure now can provide a
  collection of tools and analysis package for
  biomolecular structure determination, refinement
  and analysis from crystallographic, EM or NMR data
  . In structural biology field, in order to reveal
  a dedicated and reliable structure of
  biomolecule, research data is acquired,
  interpreted, published, reused, and sometimes
  eventually discarded. Creative Biostructure helps
  the development of appropriate infrastructural
  services, ones which make it easier and
  time-saving for researchers to collect, read and
  process the data and obtain the expected and
  target structure results.

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Project Objectives
With this deliverable, the project has reached or
the deliverable has contributed to the following
objectives, including but not limited to
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Crystallographic data processing and structure
determination

• The physical infrastructure for X-ray
  crystallography structural biology includes
  synchrotrons, which are affordable by a nation.
  There are 47 in the world (lightsources.org).
  Each synchrotron provides a number of beamlines
  for experiments, usually including several
  optimized for macromolecular X-ray
  crystallography, often some for other structural
  biology techniques including SAXS (Small-Angle
  X-Ray Scattering) and CD (Circular Dichroism),
  and usually some beamlines for material sciences
  and other non-biological applications. Creative
  Biostructure has access to the most modern and
  popularly used synchrotron X-ray resources, such
  as ALS, SSRL, CAMD, Photon Factory, SSRF, etc.

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EM data processing and interpretation

• Improvements in microscopes, direct electron
  detectors, and processing software have led to a
  rapid increase in the number of high resolution
  cryoEM structures the resolution revolution.
  This has led in turn to significant investments
  in electron microscopes around the world.
  Structural biologists in Creative Biostructure
  are working on harder targets fewer single
  proteins, larger macromolecular assemblies, more
  membrane proteins.

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NMR data processing and interpretation

• Creative Biostructure has access to the
  Structural Biology NMR Resource to obtain
  high-resolution solution NMR spectrometers
  ranging from 300 MHz to 900 MHz in field
  strength. These are used for small molecule
  analysis and for studies of macro-molecular
  structure, dynamics, and function. Our highly
  trained associates assist in the routine data
  collection and routine data interpretation, for
  training in instrument usage, for performing data
  processing and interpretation and to partner for
  more extended collaborative studies of protein or
  nucleic acid structure and dynamics.

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Contact Creative Biostructure

• Mailing Address 45-1 Ramsey Road Shirley, NY
  11967, USA
• Email Address contact_at_creative-biostructure.com
• Website http//www.creative-biostructure.com