POSITIVE RESPONSE vs [CONCENTRATION] - PowerPoint PPT Presentation

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POSITIVE RESPONSE vs [CONCENTRATION]

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NEGATIVE (inhibitory) RESPONSE vs [CONCENTRATION] Outcome [ML] [Y] J0 ... RESPONSE vs LOG [CONCENTRATION] log [Inhibitor] COMP, UNCOMP, NONCOMP. Outcome [ML] ... – PowerPoint PPT presentation

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Title: POSITIVE RESPONSE vs [CONCENTRATION]


1
POSITIVE RESPONSE vs CONCENTRATION
Outcome
max
ML
Y
Jo
vo
RESPONSE
Lfree
X
Ao
S
molecule
2
1/RESPONSE vs 1/CONCENTRATION
Outcome
1/ML
1/Y
1/Jo
1/vo
1/RESPONSE
1/Lfree
1/Ao
1/S
1/X
1/molecule
3
RESPONSE vs LOG CONCENTRATION
Outcome
max
ML
Y
Jo
vo
RESPONSE
logX
log Lfree
logAo
logS
log molecule
4
NEGATIVE (inhibitory) RESPONSE vs CONCENTRATION
Outcome
max
comp
-Inhib
mixed
MLYJ0v0RESPONSE
uncomp
Lfree Ao S X
molecule
5
1/RESPONSE vs 1/CONCENTRATION
Outcome
MIXED
COMP
1/ML1/Y1/J01/v01/RESPONSE
UNCOMP
- Inhibitor
1/Lfree 1/A0 1/S 1/X
1/molecule
6
RESPONSE vs LOG CONCENTRATION
Outcome
max
COMP
MLYJ0v0RESPONSE
NONCOMP
UNCOMP
log Lfree logAo logS logX
log molecule
7
NEGATIVE (inhibitory) RESPONSE vs CONCENTRATION
Outcome
- Inhibitor
Fixed L, Ao, S, Xnon saturating
MLYJ0v0RESPONSE
saturating
Inhibitor COMP, UNCOMP, NONCOMP
8
RESPONSE vs LOG CONCENTRATION
Outcome
- Inhibitor
MLYJ0v0RESPONSE
Fixed L, Ao, S, Xnon-saturating
saturating
log Inhibitor COMP, UNCOMP, NONCOMP
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