CELIAC DISEASE BY EMER BYRNE

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CELIAC DISEASEBY EMER BYRNE

• Koiliakos (greek) abdominal
• Endemic Spure (chronic form of mal-absorption
  syndrome)
• Gluten Enteropathy
• Non-tropical Spure

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CHARACTERISTICS

• Autoimmune Disease (delayed allergy)
• (Triggered surgery, pregnancy, viral
  infection)
• Small Bowl
• Reaction to Gliadin gly-eh-din
• (Gluten protein found in Wheat)
• Children (9-24mts) Bowl symptoms
• Adults Malabsorption related problems

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PATHOLOGY

• Exposure to Gliadin
• Enzyme Tissue Transglutaminase modifies
• Cross-reaction with bowl tissue
• Inflammatory reaction
• Flattening in villi
• Interfering in absorption of nutrients

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SYMPTOMS

• Fatigue
• Chronic Diarrhea
• Failure to thrive (children)
• Weight loss (adults)
• Malabsorption related symptoms
• - Anemia (fe def, and megaloblastic)
• - Vit. K def
• - Osteopenia (Ca and Vit D def)

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COMPLICATIONS

• Lymphoma
• Adenocarcinoma
• Osteoporosis
• Ulcerative jejunitis and stricturing
• (ulcers and narrowing)

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FOODS TO AVOID

• All foods containing wheat, barely, rye and oats
• - bread, pasta, cereals and beer
• Artificial flavourings and colourings
• Crisps and sweets
• Vitamins, Medicines
• Specific spirits
• Stamp and Envelope adhesives

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DIAGNOSIS

• Blood tests
• - IgA
• - Anti EMA ( Endomysium)
• - Anti TTg ( Tissue Transglutaminase)
• Endoscopy ( Gold standard)

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ENDOSCOPY

• Upper GI Endoscopy
• - EGD ( esophagogastroduodenoscopy )
• Visual examination of upper GI
• Lighted, flexible fibro-optic or video scope
• 15-30 mins
• Outpatient procedure
• No pain

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Pathologic Duodenum Normal
Duodenum
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TREATMENT

• Lifelong gluten-free diet
• - Potato
• - Rice
• - Unprocessed meat, fish, fruit and
  vegetables
• - Wine
• - Rum and Tequila

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GLUTEN-FREE FOODS

• Most foods are now available in gluten-free

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PROGNOSIS

• Intestinal damage begins to heal within weeks

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WHY NOW??

• Glutens very cheap and tasty
• - used more and more in unprocessed foods
• - larger profits for food manufactories
• Water soluble gliadin Problem
• - fine grinding, baking, fermenting, chemical
  treatment and synthesis

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EPIDEMIOLOGY

• 1 of Indo-Europeans
• - Celtics
• - Balts
• - Germanic Peoples
• - Latins
• - Slavs
• Prevalence
• - 1/300 Ireland
• - 1/133 America (3 million)

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• THANK YOU FOR YOUR ATTENTION

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REFERENCES

• http//www.celiac.org/
• http//www.celiac.nih.gov/
• http//digestive.niddk.nih.gov/ddiseases/pubs/celi
  ac/
• http//www.csaceliacs.org/
• http//www.glutenfreeoats.com/