What - PowerPoint PPT Presentation

About This Presentation
Title:

What

Description:

Case Study 3 Long-term Proton Pump Inhibitor Therapy and Risk of Hip Fracture What s in the Bag? Lecture 5 Section 1.4.3 Wed, Aug 29, ... – PowerPoint PPT presentation

Number of Views:7
Avg rating:3.0/5.0
Slides: 23
Provided by: RobbKo5
Learn more at: https://people.hsc.edu
Category:
Tags: proton | therapy

less

Transcript and Presenter's Notes

Title: What


1
Whats in the Bag?
  • Lecture 5
  • Section 1.4.3
  • Wed, Aug 29, 2007

2
How Strong is the Evidence?
  • Rather than give an accept/reject answer, we may
    ask a different question
  • How strong is the evidence against H0?
  • We use the p-value to measure this.

3
The p-value
  • In the Bag A/Bag B example, if the selected token
    is worth 50, what is the p-value?

4
Two Bags
Observed value
5
Two Bags
Bag A
50
-1000
10
20
30
40
60
1000
Bag B
50
-1000
10
20
30
40
60
1000
6
Two Bags
p-value 2/20 0.10
Bag A
50
-1000
10
20
30
40
60
1000
Bag B
50
-1000
10
20
30
40
60
1000
7
The p-value
  • If the selected token is worth 30, what is the
    p-value?
  • Keep in mind, we may always compute the p-value
    regardless of our decision about which hypothesis
    to accept.

8
A Two-Sided Test
Bag F
5
1
2
3
4
6
8
10
9
7
9
A Two-Sided Test
  • If the selected token is worth 8, what is the
    p-value?
  • First, what is the direction of extreme?
  • Which values are at least as extreme as 8?

10
A Two-Sided Test
Observed value
Bag F
5
1
2
3
4
6
8
10
9
7
11
A Two-Sided Test
Equally extreme
Observed value
Bag F
5
1
2
3
4
6
8
10
9
7
12
A Two-Sided Test
At least as extreme as 8
At least as extreme as 8
Bag E
5
1
2
3
4
6
8
10
9
7
Bag F
5
1
2
3
4
6
8
10
9
7
13
A Two-Sided Test
p-value 12/30 0.40
Bag E
5
1
2
3
4
6
8
10
9
7
Bag F
5
1
2
3
4
6
8
10
9
7
14
The p-value
  • If the selected token is worth 1, what is the
    p-value?

15
Shortcut
  • In a two-sided test, if the null distribution is
    symmetric, then you can compute the probability
    in one direction, and then double it to get the
    p-value.

16
The p-value
  • A small p-value is strong evidence against the
    null hypothesis.
  • Why?

17
Two Explanations of Unusual Observations
  • The null hypothesis leads us to a certain
    expectation of what the data will show.
  • If the data deviate from our expectation, then we
    need to explain that deviation.

18
Two Explanations of Unusual Observations
  • Two explanations
  • The null hypothesis is true the deviation is due
    to chance.
  • The null hypothesis is false we had the wrong
    expectation in the first place.

19
Two Explanations of Unusual Observations
  • Chance is a fine explanation if the deviation is
    small.
  • Chance is not a very good explanation if the
    deviation is large.
  • Thats where the p-value comes in.

20
Two Explanations of Unusual Observations
  • Small deviations are consistent with the null
    hypothesis.
  • They have high probability (large p-values) if
    the null hypothesis is true.

21
Two Explanations of Unusual Observations
  • Large deviations are inconsistent with the null
    hypothesis.
  • They have low probability (small p-values) if the
    null hypothesis is true.

22
Case Study 3
  • Long-term Proton Pump Inhibitor Therapy and Risk
    of Hip Fracture
Write a Comment
User Comments (0)
About PowerShow.com