?????(Bacillus subtilis , natto)???

1
???/???????
2
???
3
?????(Bacillus subtilis , natto)???

• ???(Bacillus subtilis natto)?????????,????????????
  ??????
• ?????????,?????????,??????????????????,???????????
  (???0111?0144?0157???),????????????????
• ???????1905???????????????????????,????????Bacillu
  s natto Sawamura?
• ???1946???Smith?????,????????????(Bacillus
  subtilis )????(??),????????????????????
• ?????????,??????,??????????????????

4
?????(Bacillus subtilis , natto)???(?)

• 1930??????????????????(Bacillus natto
  No.1)?????????,?????????????????,?????????????,???
  ????????????????
• ??,??Bacillus natto?Bacillus megaterium??????(pro
  toplastfusion),????????,??????????B12,????????????
  ??
• ????????(N-methyl-N-nitro-N-nitrosoguanidine,
  NTG)????????(B. natto Miyagino),???????????,??????
  ???????,??????????????????

5
??????

• 1?????????,?????????????????????
• 2?????????????????
• 3????????????,?????????????????
• 4?????????(100??????20??),?????????????
• 5?????98??????6???

6
??????(?)

• 6????????(???)?????????
• 7????????????????????(Salmonella
  typhi)???????(Shigella dysenteriae)???????(Shigell
  a flexneri)???????(Shigella sonnei)????????(Staphy
  lococcus aureus)?????????
• 8??????????????,?????????????,??????????(????????)
  ??

7
???
8
??????

• ???(lactic acid bacteria)????????,???? ?????????
• ?????????,?????????????(homofermentation)?????????
  ?????????????????(heterofermentation)??
• ??

9
????????

• L. delbrueckii spp.bulgaricus , L. acidophilus,
  L. casei , L. fermentum ,L. plantarum , L.
  brevis , L. lactis , ?L. reuteri???????
• ?????Bifidobacteria??B. adolescentis , B.
  animalis , B. bifidum , B. infantis , B.
  longum?B. thermophilum??
• ?????(streptococci)??S. salivarius ssp.
  thermophilus.

10
??????

• (1)???????????????????????????
• ?????????????,????????????????,????????
  ?,??????niacin?thiamine?riboflavin?pyridoxing?vita
  min K????(Denter and Bisping,1994)?
• (2)?????????????
• Hose?Sozzi(1991)????Bifidobacteria?Lact
  obacilli???????Salmonella typhimurium?Clostridium
  difficile?Campylobacter jejuni?Escherichia
  coli?Shigella spp.??????????,????????????

11
??????(?)

• (3)??????????????
• ??????????????????,???????????????(Majam
  aa et al.,1995)?
• (4)LAB??????????????????????????(bacteriocins)????
  ???????

12
???/?????
13
?6??????????????
(????????,?????? 1998)
14
?7????????????????(?????)
????Apple. and envi.Microbiol. sep. 2001
15
?????????(100??? ???20??),??????? ?????? ? ???
MAX. 90 ????? ?5??
16
The End