ACADEMIC NEUROSCIENCE RESEARCH IN FRANCE

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ACADEMIC NEUROSCIENCE RESEARCH IN FRANCE
Pr André Syrota Inserm, Chairman and CEO
05.06.2009
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NEUROSCIENCE RESEARCH

• LONG LASTING TRADITION IN NEUROSCIENCE RESEARCH
• STRUCTURES OF EXCELLENCE
• IMPORTANT CONTRIBUTIONS TO NEUROSCIENCE KNOWLEDGE

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STATE OF THE ART
NORD PAS DE CALAIS

• 550 Research teams
• 3300 Researchers, engineers and students
• 18 Clinical investigation centres
• 4200 Publications/Year
• 220 millions (salaries excluded)

HAUTE NORMANDIE
BASSE NORMANDIE
LORRAINE
ILE DE FRANCE
BRETAGNE
ALSACE
PAYS DE LA LOIRE
CENTRE
BOURGOGNE
POITOU- CHARENTES
RHONE-ALPES
AUVERGNE
AQUITAINE
PACA
MIDI PYRENEES
LANGUEDOC ROUSSILLON
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STATE OF THE ART
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FOUNDATIONS FOR SCIENTIFIC COOPERATION

• ALZHEIMER AND RELATED DISEASES Maladie
  dAlzheimer et maladies apparentées, as part of
  the presidential plan.
• PSYCHIATRY FondaMental
• SENSORY ORGANS Voir et Entendre
• NEUROLOGICAL DISABILITIES NeuroDis
• FUNDAMENTAL RESEARCH Ecole des Neurosciences de
  Paris

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ALZHEIMERS DISEASE PLAN

• 860 000 French Alzheimers patients
• Cost of the disease in Europe 55 billion /year
• Announcement on February 1rst, 2008
• A program from 2008 to 2012
• 3 axes, 11 goals, 44 measures
• Joint Programming Initiative
• 1,6 billion euros over 5 years
• Medico-social aspects 1,2 billion
• Health component 200 millions
• Ambitious research component 200 millions

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ORGANISATIONAL CHANGES SIMPLIFICATION AND
COORDINATION

• COORDINATION
• The National Alliance of Life Sciences and Health
  (INSERM, CNRS, CEA, INRA, Institut Pasteur,
  INRIA, IRD, Conference of Presidents of
  Universities, Conference of General Directors of
  Academic Medical Centers)
• AN ORGANISATIONAL AND OPERATIONAL STRUCTURE
• Creation of 10 institutes including an Institute
  of Neurosciences, Neurology and Psychiatry

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EUROPEAN APPROACH ESFRI BIOMEDICAL RESEARCH
INFRASTRUCTURES
biobanking model validation
samples data biomarkers
samples data targets biomarkers
targets
INSTRUCT Structural Biology
BBMRI Biobanks Biomolecular Resources

EATRIS Translational
INFRAFRONTIER Animal models
ECRIN Clinical Res.
ELIXIR Bioinformatics
Target Id
Target Val
Hit
Lead
Lead Optim
Preclin
Phase I
Phase II
Phase III
Research
Discovery Development
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TRANSLATIONAL RESEARCH
Discovery
Validation
Proof of principle
Optimisation
Clinical testing
Proof of concept
Pre-clinical testing
Potential application
Mechanism
Possible applicationin human
Refining application
SafetyEfficacy
Testing in human
Basic research
Testing in models
From proof of principle to first proof of concept
in human
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EATRIS (EUROPEAN ADVANCED TRANSLATIONNAL RESEARCH
INFRASTRUCTURE IN MEDICINE)
SHFJ
Limagerie préclinique pour les biothérapies
A NETWORK OF TRANSLATIONAL RESEARCH IN
NEUROSCIENCES
Institut du Cerveau et de la Moelle
Transfert to clinic