KAWASAKI SYNDROME

1
KAWASAKI SYNDROME
2

• An acute, distinct, self-limited, febrile disease
  of children
• Mucocutaneous lymph node syndrome
• vasculitis of coronary blood vessels with
  potential dilation, aneurysms, thrombosis,
  rupture, or myocardial ischemia
• 25 develop cardiac sequelae

3

• Incidence/Prevalence in USA Worldwide, affects
  all races but most prevalent in Japan
• In the US, the annual incidence rate is 0.6
  cases/100,000 children under 5 years old
• Seasonal variation - increased in winter and
  spring.
• Increased outbreaks at 2-3 year intervals

4

• Predominant age 1-5 years 50 are old, 80 are
• seen after 8 years of age

5
Diagnostic Criteria

• Fever lasting greater than 5 days plus 4 of the 5
  following
• Polymorphous rash
• Bilat. Conjunctiva injection
• 1 or more mucous mb changes
• Diffuse injection of oral/pharyngeal mucosa
• Erythema or fissure of the lips
• Strawberry tongue
• Acute cervical lymphadenopathy
• 1 or more extremity changes
• Erythema of palms /or soles
• Indurative edema of the same
• Membranous desquamation of the fingertips

6
Treatment

• IV fluids
• Pacemakers, inotropic agents, diuretics
• ASA 80-100mg/kg/day fro 14 days followed by
• IVIG 2gm/kg single IV bolus

7
TAKAYASU ARTERITIS
8

• Asian population
• Affects young adult populations
• Affects large elastic arteries
• Aorta major branches renal

9
ALLERGIC ANGIITIS/CHURG- STRAUSS SYNDROME
10

• Occurs in patients with asthma
• Middle age menwomen
• Eosinophilia 10 WBC
• Mono or Polyneuropathy
• Transitory Pulmonary infiltrates
• Paranasal sinus Abnormalities
• Biopsy - Extravascular eosinophils

11
(No Transcript)
12
(No Transcript)