Subacute measles encephalitis SME: a new AIDS defining disease

1
Subacute measles encephalitis (SME)a new AIDS
defining disease

• SME a rare and severe measles complication in
  immune suppressed patients (4 HIV pts)
• Measles in immune suppressed patients
• Atypical exanthema, IgM non conclocusive
• SME occurs 2-12 months after exposure
• SME as a cluster during 2 consecutive measles
  epidemics in Romania (32 pts)
• Myoclonus as characteristic symptom

2

• Diagnosis confirmation
• Immunocytochemistry
• PCR-CSF (evaluation)
• Treatment poor resp.
• High mortality 90
• Practical issues
• low protection against measles in this pts.
• need for treatment
• emerging diseases
• Under diagnosis

Subacute myoclonic measles encephalitis