Fig. 10.7 Negative selection

1
Fig. 10.7 Negative selection requires both
self-Ag and self-MHC
2
Fig. 10.9
3
(No Transcript)
4
Fig. 10.10 T-cell signalling
kinase
5
GADS Brb2-like adaptor downstream of Shc GEF
guanine nucleotride exchange factor LAT linker
of activated Tcells SLP76 SH22-containing
leukocyte-specific protein of 76 kD ZAP70 zeta
associate protein of 70 kD
6
Fig. 10-11
7
Fig. 10-12
8
Fig. 10-15 Clonal anergy vs. expansion
9
Fig. 10-17
10
Fig. 10-18 Different properties of APCs
11
Fig. 10-19 Apoptosis
12
(No Transcript)
13
Fig. 11-1 B-cell development
14
Fig. 11-2 SCFStem cell factor c-Kittyr
kinase Maturation of progenitor B cells requires
bone marrow
15
Fig. 11-3
16
Fig. 11-4
17
(No Transcript)
18
Fig. 11-5 TI vs. TD ags elicit 2 signals
19
Fig. 11-7 Initial signal transduction phase
Tyr kinases
Immunoreceptor tyr-based activation motifs
20
Fig. 11-8 Some Signaling pathways
21
Fig. 11-9
22
Fig. 11-10
23
Fig. 11-11
24
Fig. 11-14
25
(No Transcript)
26
Fig. 11-16
27
Fig. 11-17 Germinal Centers--B cells migrate to
the center of a secondary folllicle
28
Fig. 11-18 Somatic hypermutation
29
Fig. 11-19
30
(No Transcript)