Diapositiva 1

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methoxydihydrosanguinarine (1)
dihydrosanguinerine (3)
methoxydihydrochelerubine (2)
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RESULTS
Table 1. Antimicrobial activity of alkaloids
isolates from Bocconia arborea. M.I.C. (1.0 -
128 µg/ml).
Sa Staphylococcus aureus ATCC 2913 Sf
Enterococcus faecalis ATCC 29212 Ec Escherichia
coli ATCC 25922 Pm Proteus mirabilis ATCC
43071  St Salmonella typhi ATCC 06539 Ca
Candida albicans ATCC 10231. NP. No tested.
gt128 were considered inactive.
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CONCLUSIONS
The antimicrobial activity of the isolated
alkaloids correlate with some of the antiseptic
traditional uses of this plant.
Dihydrosanguinarine(3)and methoxidihydrochelerubi
ne(2) showed important antimicrobial activity,
but the alkaloid which showed the best activity
was methoxydihydrosanguinarine (1). The other
alkaloids were not active. Sanguinarine (3)
differs from the other compounds by the fact that
the hydrogen at C6 has been replaced by a
different chemical group. These results indicate
that the presence of a methoxyl group at C6
increases the antimicrobial activity, since
replacing the substituent at C6 by a huge group,
such as the acetonyl (5) or a monomer
(sanguidimerine 6), the activity is lost.