Ppar PowerPoint PPT Presentations

PPAR

... since the partial introduction of the new payroll system ... one employee in the northwest had been paid 1million in error by the system. Political Issue ...

PPAR agonists increase collagen content potentially improving plaque stability. Meisner F et al. Arterioscler Thromb Vasc Biol. 2006;26:845-50. ...

... Blood Glucose and Vascular Risk in Diabetes ACCORD and ADVANCE: ... Serum Creatinine and Glomerular Filtration The Concept of a Balanced Dual PPAR ...

in CV risk reduction Genetic background Food intake excess Physical inactivity Obesity Hyperglycemia Hyperinsulinemia Insulin Dyslipidemia Inflammation

... Effect of Tesaglitazar vs Pioglitazone on Lipid Measures Tesaglitazar: Effect on Serum Creatinine and Glomerular Filtration Dual a/g PPAR Agonist: ...

VBWG. Potential role of PPAR activation. in CV ... 2003;302:406-7. Peroxisome proliferator-activator. receptors ... Pioglitazone Actos Eli Lilly/ 1999 Takeda ...

Peroxisome Proliferator Activated Receptors PPARs in Agerelated Macular DegenerationLike Lesions in

... A1c on Cardiovascular Disease in T2DM Insulin Resistance Is Associated With or Directly Responsible for Factors Causing Atherothrombosis UKPDS 35: ...

... factors. 3 subtypes. PPAR a -liver and skeletal muscle ... Kidney cells from male adult African green monkey. PPAR cDNA placed in expression vector (pSG5) ...

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor g (PPARg) Jurgen Lehmann et al., 1995, Journal of ...

** gene polymorphisms ApoE gene, CETP gene promoter, adiponectin gene, PPAR- , PPAR- gene, coagulation factor genes ...

... PPAR- Ligands Endogenous PPAR- ligand Activation of PPAR- in fat cells increases fatty acid and triglyceride uptake and storage as well as impacts ...

DISLIPEMIAS. UN FACTOR DE RIESGO SIEMPRE VIGENTE. Dr Marcos Baroni ... Trigliceride levels are decreased with PPAR y. HDL are increased with PPAR y ...

PPAR-gamma activation by different ARBs Compared with the thiazolidinediones, a subset of ARBs (telmisartan and irbesartan) act as selective PPAR-gamma modulators ...

Effects of / PPAR Activation. Nuclear receptors that function as transcription factors regulating the expression of genes Insulin . sensitivity

... SOM230 Dopamin agonists: bromocriptine, cabergoline PPAR- binding agents: rosiglitazone (avandia) METYRAPONE FOR CUSHING S DISEASE Years 1978 ...

Figure 3 Transcriptional regulation mediated by PPARs and LXRs Choudhury RP et al. (2005) Mechanisms of Disease: macrophage-derived foam cells emerging as therapeutic ...

Center for Molecular Toxicology and Carcinogenesis, ... is evidence that activation of PPARb/d can either potentiate or attenuate cancer. ...

Obesity and insulin resistance is increasing and will ... Adipose. tissue. Ligand. PPAR. Target gene. Lipogenesis. Fat cell differentiation. Control of genes ...

Fancy MIS framework with template processes. Big basket for corporate eggs ... It's appaling stuff.' Enda Kenny, Fine Gael Leader. PPARs could've paid for: ...

Increasing safety and delivery convenience. Individualised, ... Crestor Atacand EPT. Emerging CDs. Insulin. resistance, PPAR agonists. EPT. Xa antagonists, ...

II. New perspectives in cardioprotection: Focus on. PPAR activation ... LV hypertrophy. With insulin resistance syndrome* Without insulin resistance syndrome ...

retinoid receptors GRIP: glucocorticoid receptor-interacting PRMT: protein Arg ... protein PGC: PPARg coactivator TRAM: thyroid hormone receptor-activator molecule ...

He, G., S. Muga, P. Thuillier, R.A. Lubert, S.M. Fischer Molecular Carcinogenesis 43: 198-205 What is PPAR-g? Peroxisome proliferator-activated receptor-gamma: member ...

Eicosapentaenoic acid (EPA) is an omega-3 fatty acid that stimulates PPAR activity ... below the skin surface, most noticeable in the thighs, buttocks, arms and face. ...

Stimulates self reactivity in autoimmune-prone strains of mice. PPAR ligands appear to stimulate anti ... Induction of IgE and IgG1 antibodies in Balb/c mice ...

2-methyl-2-phenoxy-propionic acid (HepagenTM - Fatro) is the only PPAR-alpha activator available in veterinary medicine. 2-methyl-2-phenoxy-propionic acid by binding to PPAR-alpha up-regulates the transcription of several genes involved in lipid and glucose metabolism. As a result it promotes the activation of mitochondrial and peroxisomal beta-oxidation pathways and liver gluconeogenesis. Enhanced lipid oxidation brings to the reduction of triglyceride accumulation in hepatocytes, recovery of liver functions and increased energy availability for glucose production. Direct up-regulation of genes involved in gluconeogenesis intensifies hepatic glucose output and restores energy balance. The anti-inflammatory properties of this PPAR agonist further help cows, considering that inflammatory conditions play a role in the pathogenesis of fatty liver and many other diseases.

Interaction with the receptor causes a conformational change ... Nucleus. PPAR. Mitochondrion. Fatty Acid Ox-n. CD36. ACC. P. GLUT4. Akt. P. P. P. AMPK. P ...

No difference between groups in HF mortality. Continued divergence in ... results support use of PPAR modulator in patients with diabetes at high CVD risk ...

PPAR activation reduces intimal hyperplasia. Wang C-H et al. Circulation. 2004;109:1392-400. ... Intimal area. Medial area. 3.1. 0.98. P 0.001. VBWG ...

The biology of peroxisomes and their effect on skin biology and diseases development

The biology of peroxisomes and their effect on skin physiology and pathology

Effects independent of the degree of glycemic control (HbA1c) ... internal elastic lamina. Gizard et al. JCI 2005;115(11) :3228-3238. transcription -1 ...

Role of the liver in the regulation of energy homeostasis ... gluconeogenesis - sterol metabolism - heme synthesis - amino acid. metabolism ...

l sions neuro-anatomiques - anomalies de la plasticit c rabrale - alt rations des voies de neurotransmission. Syndrome d'alcoolisation f tale et vuln rabilit r gionale ...

Endocrine Pathology Companion Meeting Genetic Alterations Involved in the Transition from Well Differentiated to Poorly Differentiated and Anaplastic Thyroid Carcinomas

Eicosapentaenoic acid (EPA) is an omega-3 fatty acid that ... Chunky. Chubby. Metabolic functions of adipose tissue. Metabolic functions of adipose tissue ...

Enhancing progenitor cell self-renewal: a new approach to stimulating red cell production Development of novel therapies for Diamond-Blackfan anemia and other ...

DNA structure. Structure of Cells. Plasma membrane. Cytoplasm. Nucleus ... Keeps the DNA molecules of eukaryotic cells separate from metabolic machinery of ...

When we do liposuction, we remove subcutaneous fat not visceral fat. ... No eat High Glycemic index foods. Low carbohydrate diet. Ornish Diet ...

When we do liposuction, we remove subcutaneous fat not visceral fat. ... Sugar Busters. Sugar and Insulin make you fat. Decrease sugar content in food. Zone Diet ...

Another CDC survey the Behavioral Risk Factor Surveillance System (BRFSS) 1998 ... orlistat, fluoxetine, phentermine, diethylpropion, bupropion, zonisamide, ...

Most patients with atherogenic dyslipidaemia are insulin resistant ... Randomised dietary clinical trials of polyunsaturated fats versus. saturated fats ...

III. Insulin sensitizers: Surrogate and clinical. outcomes studies. IV. ... N = 266 Hispanic women with gestational diabetes randomized ...

... function of visceral fat. Future research ... Visceral Fat Associates with ... Some Patients have Predominant Visceral Fat. Obesity Is An ...

of polymeric Chitosans (US and Norway origin) and KP 2647TM on suppression of lipid droplet in ... (Microscope of rat liver-tissue) 7.5% EtoH 20mg KP 2647. 7.5 ...

It has been shown that atherosclerosis is an inflammatory disease. ... and its transportation agent low-density lipoprotein (LDL) play an important ...

Number at risk Pioglitazone 2488 2373 2302 2218 2146 348 Placebo 2530 2413 2317 2215 2122 345 5 10 15 25 0 6 20 0 12 18 24 30 36 Pioglitazone (514 events) ...

The Regulation of Eukaryotic Gene Expression..using the example of PEPCK PEPCK This is an acronym for an enzyme PhosphoEnol Pyruvate CarboxyKinase This enzyme is ONLY ...

survey of 144 primary ... Results : - LDL cholesterol lower in the atorvastatin-group (79 ... ADIPOSE TISSUE IS THE MOST IMPORTANT ACTION OF TZD. Mechanisme van ...

Uterus, testis, pituitary, ovary, epididymis, and adrenal gland. ER-b (Kuiper et al. 1996) brain, kidney, prostrate, ovary, lung, bladder, intestine, and epididymis. ...

Other partners may include the City with J-15 tax abatements. ... (Dept. of Housing Preservation & Development) may offer low rate second mortgages. ...

Dr' M' Balasubramanyam

http://creativecommons.org/licenses/by-sa/2.0/ * * * * * * Decreased glucose tolerance Muscle insulin resistence b Cell compensation Increased gluconeogenesis in ...

Molecular Predictors of 3D Morphogenesis by Breast Cancer Cells in 3D Culture Ju Han Imaging & Informatics Lab Life Sciences Division http://vision.lbl.gov