Auditory Processing - PowerPoint PPT Presentation

Title: Auditory Processing


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Auditory Processing
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05-34
W. W. Norton
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05-33
W. W. Norton
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05-36
W. W. Norton
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W. W. Norton
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Mapping the Auditory System in Rhesus Monkeys
Neuroscience Program
University of Iowa
The University of Iowa Department of
Psychology Behavioral and Cognitive Neuroscience
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Visual Processing Streams
WHERE
WHAT
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Auditory cortex
Unfolded view of supratemporal plane and
adjoining STG.
Core
Belt
Parabelt
Kaas and Hackett, PNAS 2000
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Auditory Projection System
Early Auditory Areas
Early Auditory Areas
MGB
MGB
IC
IC
Lower Brainstem
Lower Brainstem
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Auditory Projection System
Early Auditory Areas
Early Auditory Areas
Corpus Callosum, Anterior Posterior Commissures
MGB
MGB
IC
IC
Tectal Commissures
Lower Brainstem
Lower Brainstem
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'Deaf' side
Intact side
Early Auditory Areas
Early Auditory Areas
MGB
MGB
IC
IC
Tectal Comm.
Lower Brainstem
Lower Brainstem
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Methods

• Three surgically prepared monkeys

• 2-DG injected intravenously

• Wide variety of acoustic stimuli

• Monkey listens passively for 45 min

• Brain prepared for autoradiography

• LCGU measured in ROIs throughout brain

• ROIs compared for hemispheric asymmetries

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Auditory Stimuli
Passive Listening
BIRDS (10)
MUSIC (12)
ENVIRONMENTAL (18)
TONES, SWEEPS, NOISE (12)
HUMAN (9)
OTHER ANIMALS (8)
MONKEYS (31)
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2 DG in Intact (left) and Deafferented (right)
Hemisphere
Early auditory areas
MGB
IC
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Hearing
Deaf
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Poremba et al., Science, 2003
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Columns of 2DG activation in rSTG
Completely Intact Monkey
Hearing Side of Deafferented Monkey
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Poremba et al., Science, 2003
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Metabolic Mapping of Visual Cortex
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Metabolic Mapping of Auditory Cortex
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Overlap of Auditory and Visual Maps
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Similar Auditory and Visual Processing Streams
Where
What
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Superior Temporal Gyrus (STG) (n7 monkeys)
Left Hemisphere
Right Hemisphere
of Whole Brain Activity
Monkey Vocalizations
Complex Sounds and Vocalizations
Complex Sounds No Vocalizations
Ambient Background Sound
Human Vocalizations
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High
Low
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High
Low
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FDG Activity in the Dorsal Temporal Pole
Left Hemisphere
Right Hemisphere
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90
of Whole Brain Activity
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Ambient Background Noise
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FDG Activity in the Dorsal Temporal Pole
Left Hemisphere
Right Hemisphere
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plt0.001
90
plt0.01


of Whole Brain Activity
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Monkey Vocalizations
Complex Sounds and Vocalizations
Ambient Background Noise
Complex Sounds No Vocalizations
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Dorsal Temporal Pole (n8 intact monkeys, n3
split brain monkeys)
Left Hemisphere
Right Hemisphere
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Split Brain Monkeys
p lt 0.001
90
of Whole Brain Activity

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Ambient Background Sound
Monkey Vocalizations
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Poremba et al., Nature, 2004
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Similar Auditory and Visual Processing Streams
Where
What
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Parabelt projections to prefrontal cortex