Proteomics and Glycoproteomics (Bio-)Informatics of Protein Isoforms Nathan Edwards Department of Biochemistry and Molecular & Cellular Biology Georgetown University ...
Cell surface glycoproteins found on Astrocytes and on Neurons. Variety of molecular ... Non-Calcium dependent cell to cell Interactions/ Adhesion. Astrocytes ...
Oligodendrocytes expressing Adenovirus QKI-6 and -7 isoforms. Top photographs show ... photographs show a coronal section of mouse brain injected with AdQKI-6 ...
Synopsis. MS/MS spectra provide evidence for the amino-acid sequence of functional ... of amino-acid sequence. Sensitive to small sequence variations. Synopsis ...
... COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs Nature Reviews Drug Discovery 5: ...
Direct Experimental Observation of Functional Protein ... Ala2Pro associated with familial amyloid polyneuropathy. Novel Mutation. Translation Start-Site ...
Table 2 Large-scale controlled clinical trials of COX2-selective drugs* ... understanding the activities of non-steroidal anti-inflammatory drugs ... A Cancer of Skin ...
'Schizophrenia is a devastating brain disorder the most chronic and ... 111 trios of affected and two parents (one trio per pedigree) 321 Cases and 242 Controls ...
Pre-translational changes in myosin isoforms, myostatin and IGF1 in stimulated skeletal muscle ... Mutation in myostatin gene leads to 'double-muscled' ...
Topic Next step: deciding which genes to clone Problem = correlating enzymes with genes Who matches the pH? Who localizes where? Which isoform if alternatively spliced?
WASps and cortactin: activate ... WASp: Hematopoietic isoform. N-WASp: Ubiquitous. Roles of N-WASp ... WASp family proteins activate Arp2/3 complex on ...
Migration is a complex cycle requiring careful coordination of many cytoskeleton ... Isoforms exhibit unique phosphorylation events (Murakami et al., Biochemistry. ...
The Steric-Blocking or 2-state Model of Myofilament Activation ' ... Structure and Distribution of the Sarcoplasmic Reticular. Ca2 ATPase (SERCA) Isoforms ...
Supplemental Figure 1. Specific siRNA treatments suppress the mRNA expression of each PLC isoform in MIN-6 cells Non-targeting (NT) siRNA (open bars; n=5) or siRNA ...
database of alternative splice events and the resultant isoform splice patterns ... Thirdly, for grant purposes, ATD - Alternative transcript diversity database, ...
Can produce up to 38016 different protein isoforms. Pre-mRNA editing by Adenosine deamination ... Drosophila. genes. Pumilio domain (Wang et al, Cell, 2002) dsRBD-RNA ...
Human cancer: a series of genetic and epigenetic alterations that can be ... Serum Amyloid A (SAA) isoform. Nasofaringe. Vlahou et al. Am J. Pathol 2002; 158:1491-1501 ...
... lung, FMO2 is the predominate isoform expressed in mouse. ... 4 female mice. AIN-93 G. diet. Harvest Lung and Liver Tissues. Isolate and Quantify RNA. Make cDNA ...
Densely packed fibrous structures called amyloid bodies. ... Many isoforms make up the amyloid proteins. Amyloid precursor protein another source of which can ...
Three isoforms of nitric oxide synthase (NOS) have been identified. ... NOS catalyzes the conversion of arginine to citrulline and nitric oxide (NO) ...
Distinction between isoforms. Overall the increased confidence of such identifications ... Two-dimensional (2D) separations. Data dependent MS-MS mode ...
Lipid Raft. CD45 isoforms and phosphatase activity. CD45 is a transmembrane phosphatase ... and cholesterol in rafts' - regions of reduced mobility ...
Homology and Homologs. Homology just means sequence similarity by ... gi|24640218|ref|NP_572350.2| CG3126-PA, isoform A [Drosophila melanogaster] Length=1571 ...
hypothetical introgression (Labate and Baldo 2005) ... a divergence estimates were not available for: ... succinic semialdehyde reductase isoform 1 (BAG16485) ...
Physiological parameters for the growing rat pup have been compiled in an ... rat and human cytochrome P450 isoforms responsible for metabolism in rats and ...
The transition from the -helical to the -sheet-rich isoform of the prion protein ... uniform in height and contain holes that make them sponge like in appearance. ...
Termination codon is on the last exon (not premature) ... 4.3% of reviewed RefSeqs have PTCs 34% have start codon after first exon. NMD is Pervasive ...
Title: Presentazione di PowerPoint Author: Toselli Mauro Last modified by: Prof Toselli Created Date: 3/16/2004 3:26:48 PM Document presentation format
Bioinformatics for Proteomics ... Under expressed Over expressed Protein Center v 3.0.4 A Proteomics bioinformatics tool available through HSLS Import ...
Antigen recognition out + - Lipid bilayer of plasma membrane in Signal transduction (contains one or more ITAMs) Src-family tyrosine kinase reversibly associated with ...
more regulating gene expression Development: differentiating cells to become an organism * Fig 16.1 Gene Expression is controlled at all of these steps: DNA packaging ...
Title: Faster, More Sensitive Peptide ID by Sequence DB Compression Last modified by: Nathan John Edwards Created Date: 12/6/2004 12:44:14 AM Document presentation format
Modulation of Transcriptional Activity of Ecdysone dependent Genes by Different Hormone Response Elements (Arial 60, bold, white) S. Schauer, S. Braun, M. Spindler ...
Title: Faster, More Sensitive Peptide ID by Sequence DB Compression Last modified by: Nathan John Edwards Created Date: 12/6/2004 12:44:14 AM Document presentation format
Protein Intrinsic Disorder, Cell Signaling and Alternative Splicing Outline of Talk Examples of intrinsically disordered proteins Prediction of natural disordered ...
Control of Gene Expression in Bacteria Gene Regulation and Information Flow: an overview Metabolizing Lactose A Model System: multiple genes, classes of mutants ...
Puffer fish. Mouse. Human. Yeast. Fruit. Fly. HS DM. 1500. 990. 450. 90. HS ... In reference to: Mouse Puffer fish Fruit fly Yeast. Implied by this trend: ...