Angiogenesis

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BME- Short Presentation SHANTE DEZRICK 11/7/12
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What is angiogenesis

• Common denominator in most common diseases.
• New capillary blood vessel growth in the body.
• Natural process for healing and reproduction.
• Precise growth factors and inhibitors are needed
  to promote the angiogenesis process.
• Too little or too much can be fatal to the body.

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Excessive

• Occurs in 70 conditions such as cancer,
  diabetic blindness, age-related macular
  degeneration, psoriasis, etc.
• New blood vessels feed diseased tissues these
  cells secrete angiogenesis growth factors.

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Insufficient

• Occurs in CAD, stroke, delayed wound healing,
  etc.
• Tissues dont produce adequate amounts of growth
  factors.
• Causes blocks and bad circulation.
• Tissues are damaged or die from not getting
  enough oxygen and nutrients (blood).

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Angiogenesis Process

1. Due to diseased or injured tissue angiogenesis
   growth factors (proteins) are released to nearby
   tissues.
2. These proteins bind to receptors on endothelial
   cells of neighboring blood vessels.
3. ECs are activated and signals are sent for the
   production of new molecules (enzymes).
4. Tiny holes are made in the basement membrane of
   the preexisting blood vessel by the enzymes.
5. The ECs divide and travel to the diseased tissue
   (tumor).
6. New blood vessel tubes are formed by sprouting
   ECs that roll up.
7. These tubes connect to form blood vessel loops
   that circulate blood.
8. Blood flow begins once the tubes are stabilized
   by special muscle cells.

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Facts Figures

• 1787 the term angiogenesis first used by
  British surgeon Dr. Hunter.
• 1975- basic fibroblast (1st angiogenesis
  inhibitor) was discovered by Dr. Folkman and Dr.
  Brem.
• 1989- Vascular endothelial growth factor (VEGF)
  was discovered.
• 1998- 1st FDA approved device for stimulating
  vessels. (TMR)

• 2003- Avastiv was the 1st anti-angiogenesis drug
  used in large scales for experimentation.
• 4 billion invested in further research.

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Treatment

• Medicine restore bodys natural growth of
  angiogenesis.
• Therapeutic inhibit or stimulate angiogenesis
  factors.

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future

• Build new functional/durable blood vessels or
  conversely prevent growth in malignant tissues.
• Better understanding to develop new drugs and
  therapy.
• Ability to treat intractable diseases. ( cancer,
  heart diseases, Alzheimers, diabetes, etc.)

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Sources

• Li, William, Michelle Hutnik, et al.
  "Understanding Angiogenesis." Angiogenesis
  Foundation. Angiogenesis Foundation, 27 2012.
  Web. 12 Oct 2012.
• O'Connor, Pat. "Angiogenesis." Lymphedema People.
  Lymphedema People, 15 2011. Web. 19 Oct 2012.
• "Coronary Angiogenesis." . Brown. Web. 20 Oct
  2012. lthttp//biomed.brown.edu/Courses/BI108/BI108
  _2003_Groups/Coronary_Angiogenesis/BCKSRC.HTMgt.
• "History of VEGF and angiogenesis research."
  BioOncology. Genentech USA, INC. Web. 13 Oct
  2012. lthttp//www.biooncology.com/research-educati
  on/vegf/ligand/overview/history/index.htmlgt.
• Bisht, Manisha. "Medknow." Medknow. 42.1 (2010)
  2-8. Web. 22 Oct. 2012. lthttp//www.ijp-online.com
  /article.asp?issn0253-7613year2010volume42is
  sue1spage2epage8aulastBishtgt.
• http//www.biooncology.com/research-education/vegf
  /images/Angiogenesis-tumor-growth.jpg
• http//www.lymphedemapeople.com/images/cascade_ima
  ge.jpg
• http//www.raneyzusman.com/storage/images/transmyo
  cardial-laser.gif
• http//www.angio.org/img/wordie.jpg