Urinary Antiseptics and Demulcents

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• Urinary Antiseptics and Demulcents

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Arctostaphylos Uva Ursi
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Arctostaphylos uva-ursi
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Arctostaphylos uva ursi
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Arctostaphylos Uva-Ursi
Arctostaphylos, from the Greek, 'arktos (arktos),
"bear, stafulh (staphyle), "grapes" uva-ursi,
from the Latin uva, "grape, berry of the vine",
ursi, bear "bear's grape" Uva-Ursi,
Kinnikinnick, Crowberry, Foxberry, Mealberry,
Mountain Box, Mountain Cranberry , Upland
Cranberry.
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Arctostaphylos Uva-Ursi
Family Ericaceae Grows throughout the Western
foothills and mountains, from California through
Alaska Part used Leaves Qualities Dry,
astringent, cold
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Arctostaphylos Uva-Ursi
Constituents hydroquinone glycosides (4-15)
arbutin, methylarbutin polypheneols , tannin
(increased in older leaves), Flavonoids
(quercetin), Acids (ursolic, gallic,
ellagic), Allantoin, Volatile oil lupeol
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Arctostaphylos Uva-Ursi

• Standardized extract 70 mg arbutin two 0.7 g
  tabs BID-TID. 400-840 hydroquinone derivatives
  calculated as water-free arbutin.
• Tincture 15 tincture 10-17 ml qd 12 2-4 ml
  TID
• Infusion 2-3 tsps/ cup boiling water. Drink 1
  cup qid. because the Ericaea leaves are tough,
  sometimes its helpful to do a modified version,
  simmering for a couple of minutes.

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Vaccinium macrocarpon
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Vaccinium macrocarpon
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Vaccinium macrocarpon

• Common name Cranberry
• Family Ericacea
• Part used Berry, juice of berry
• Constituents hippuric acid, Proanthocyanadins,
  Vitamin C
• Cranberries contain proanthocyanidins (PACs) that
  can prevent the adhesion of bacteria to the
  urinary tract wall. The anti-adhesion properties
  of cranberry may also inhibit the bacteria
  associated with gum disease and stomach ulcers.
• Important note the mechanism of action is not
  due to acidification of the urine.

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Impact of cranberry on Escherichia coli cellular
surface characteristics.

• The anti-adhesive effects of cranberry have been
  attributed to both interactions of its components
  with the surface of bacterial cells and to
  inhibition of p-fimbriae expressionHere, we show
  that the morphology of E. coli is changed when
  grown in the presence of juice or extract from
  Vaccinium macrocarpon (cranberry). Gene
  expression analysis indicates the down regulation
  of flagellar basal body rod and motor proteins.
• Johnson BJ, Lin B, Dinderman MA, Rubin RA,
  Malanoski AP, Ligler FS. Biochem Biophys Res
  Commun. 2008 Dec 19377(3)992-4. Epub 2008 Oct
  26.

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Vaccinium macrocarpon

• Medicinal action Bacteriostatic
• Medicinal uses Acute urinary tract infection
• Contraindications It has no known toxicity, and
  appears to be safe in pregnancy and lactation.

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Vaccinium macrocarpon

• Dosing
• Standardized extract 400-500 mg TID
• Tincture (14) ½ tsp tid-qid
• Non-etandardized encapsulated products vary
  widely in strength, and relative dose
  recommendations (usually around 5000 mg qd of
  fresh cranberry equivalent or 1500 mg qd
  cranberry juice equivalent)..
• Fresh cranberry juice 0.5 L/day. It is important
  to note that this needs to be pure cranberry
  juice that is sugar free. .. or is it so
  important?

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Chimaphila umbellata
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Chimaphila umbellata

• Common names Pipsissewa, Princes Pine, Winter
  Green (not the same as Gaultheria procumbens)
• Family Ericaceae
• Part used Herba
• Grows locally and throughout the temperate
  regions.
• Constituents Arbutin, chimaphillin, methyl
  salycilate, tannins.
• Actions Astringent, antimicrobial (arbutin),
  tonifying, diuretic
• Indications Acute urinary tract infections

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Chimaphila umbellata

• Dosing
• Tincture 2.5-5 ml BID-QID
• Infusion2-3 tsps/ cup boiling water. Steep 5-10
  minutes. Drink 1 cup 3-5x per day

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(Barosma betulina) Agathosma betulina
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Agathosma betulina

• Common name Buchu
• Family Rutaceae
• Part used Leaves
• Native to South Africa
• Volatile oil (2) diosphenol (buchu camphor),
  pulegone, () and (-) isopulegone,
  8-mercapto-p-menthan-3-one, 8-acetylthiomenthone,
  piperitone epoxide ()-menthone, isomenthone,
  p-cymol, limonene, terpineol
• Flavonoids rutin, diosmin, hesperidin, quercitin
  and derivatives
• Miscellaneous B-vitamins, tannin and mucilage.

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Agathosma betulina

• Medicinal Action Urinary antiseptic, stimulating
  diuretic, diaphoretic
• It also has some nervine action, and can be used
  when there is anxiety accompanying urinary
  inflammation.
• Dosing
• Dried leaf 3-6 g qd
• Tincture (12) 1-2 ml BID, (15) tincture 2.5-5
  ml BID
• Infusion 1-3 tsp/cup water infused for 10 min, 1
  cup TID

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Agropyron or Elymus repens
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Agropyron or Elymus or Elytrigia repens
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Agropyron repens

• Common name Quack Grass, Couchgrass
• Family Graminaceae
• Distribution A common pest plant in temperate
  regions. Invades lawns and landscapes
• Constituents
• Saponins
• Carbohydrates (3-8 triticin polysaccharide, 2-3
  inositol and mannitol, 10 mucilage)
• Volatile oil (agroyprene), fixed oil
• ? carotene, Minerals (silica, iron, potassium),
  Silicic acid and silicates

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Agropyron repens

• Medicinal action
• A saponin and carbohydrate (mannitol) based
  diuretic
• Demulcent
• Antimicrobial
• Expectorant

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Agropyron repens

• Decoction
• 2 tsp/cup water. Bring to boil, simmer x 10 min.
  Drink TID.
• Tincture (15 25) 3-6 ml tid
• No toxicity or contraindications

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Zea mays
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Zea Mays (Maydis stigmata)

• Common name Cornsilk
• Family Graminaceae/Poaceae
• Part used Flower Pistils
• Saponins, allantoin, sterols (beta-sitosterol,
  stigmasterol ), alkaloid (hordenine), vit. C,
  vit. K, potassium, carbohydrates including
  mucilage cryptoxanthin, anthocyanins, plant
  acids, fixed oil (2), essential oil (0.1)
  carvacrol, terpenes, bitter compounds,
  polyphenols (12), potassium salts

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Zea Mays (Maydis stigmata)

• Acute 2-4 g/day infused in 1-2 Qt/day or 1 cup
  every hour 1tsp. 0.5g
• Best as a cold infusion.
• Tincture (15 25) 3-18 ml /day

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Parietaria judiaca
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Parietaria judiaca

• Family Urticaceae
• Name Pellitory-of-the-wall
• Pariet or pared means wall
• Used to be called P. officinalis, and there is
  still controversy over whether p. judiaca is the
  same species or slightly different from P.
  judiaca.
• Pollen is highly allergenic and sticky plant
  often called sticky weed

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Parietaria judiaca

• Diuretic and demulcent
• High in flavonoids and potassium
• Most useful for inflammatory conditions of the
  kidney or bladder
• Nephritis
• Cystitis
• Considered a trophorestorative to the kidneys
• Sylibum of the Kidney

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Parietaria judiaca
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Case 1

• 63 year old woman with an extensive history of
  recurrent cystitis treated using antibiotics.
• Had bladder lift surgery 5 years ago to correct
  a malformed urethra and prolapsed uterus. The
  UTIs did not stop, and she suffered extensive
  nerve damage.
• She must self-catheterize to void her bladder if
  it fills past a certain point. She takes
  prophylactic antibiotics, which affects her
  digestion and promotes yeast infections.
• Also a long history of anti-anxiety,
  anti-depressant, and sedative medications x 40
  years.

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• At this point she seeks help from a naturopath,
  since the medical help she has gotten so far has
  only made things worse over the years.
• What can we do for her?

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Urinary Formula

• Arctostaphylos uva ursi 2 parts
• Agathosma betulinum 2 parts
• Achillea millefolium 1 part
• Elymus repens 2 parts
• Parietaria judiaca 2 parts
• Zea mays 1 part
• Infusion one tablespoon per cup. 4 cups per
  day. Sweeten with mannose.
• Also drink 8 oz. cranberry or blueberry juice per
  day.

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Other treatment considerations

• Exercises for strengthening the pelvic floor
  muscles.
• Gradually work toward discontinuing the
  anxiety/depression/sleep meds
• Use diet and supplementation to support healthy
  brain chemistry
• Regular counseling
• Probiotics, bitters, astringents to restore
  digestive health
• Vaginal suppositories to restore normal pH and
  flora
• Boric acid, Hydrastis, vitamins A E,
  Acidophillus

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REMEMBER

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