Granzyme B

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Granzyme B
SIGMA-ALDRICH
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Granzyme B Granzyme B and perforin, proteins
released by an effector cell (cytotoxic T cell),
can induce apoptosis in target cells by forming
transmembrane pores and through cleavage of
effector caspases such as caspase-3. In addition,
caspase-independent mechanisms of granzyme
B-mediated apoptosis have been suggested.
Caspase-activated DNAse (CAD) is activated
through the cleavage of its associated inhibitor
ICAD by caspase-3. CAD is then able to interact
with components such as topoisomerase II (Topo
II) to condense chromatin, leading to DNA
fragmentation and ultimately apoptosis.