arrestins in GPCR Desensitization

1
(No Transcript)
2
ß-arrestins in GPCR Desensitization
3
How Lisp Will Save the World
4
(No Transcript)
5
(No Transcript)
6
15 abstracts
15,596 abstracts
15,596,125 abstracts
7
Cyanobacteria
http//www.anselm.edu/homepage/jpitocch/genbios/27
-11x1-Cyanobacteria.jpg
8
(No Transcript)
9
Prochlorococcus
10
Tools for Thought
11
(No Transcript)
12
(No Transcript)
13
(No Transcript)
14
(No Transcript)
15
Qualitative Quantitative
Not enough data
16
(No Transcript)
17
(No Transcript)
18
Qualitative Quantitative
Not enough data
Cant do operating logics
19
ß-arrestins in GPCR Desensitization
20
Qualitative Quantitative
Not enough data
Cant do operating logics
Not expressive enough
21
Parts Processes Dynamics Operating Logic
22
(No Transcript)
23
ß-arrestins in GPCR Desensitization
24
www.biocarta.com
25
Eukaryotic protein translation
www.biocarta.com
26
Action of PPARa, PPARb(d) and PPARg and effects
on gene expression
www.biocarta.com
27
Granzyme A mediated Apoptosis Pathway
www.biocarta.com
28
Multi-step Regulation of Transcription by Pitx2
www.biocarta.com
29
Cell Cycle G2/M Checkpoint
www.biocarta.com
30
p53 Signaling Pathway
www.biocarta.com
31
Double Stranded RNA Induced Gene Expression
www.biocarta.com
32
(No Transcript)
33
PhotoSynthesis (light reactions)
Photosynthesis (light reactions)
http//www.bio.ic.ac.uk/research/barber/photosyste
mII.html
34
How Lisp Will Save the World
Biological models are complex webs of
parts, processes, dynamics, and operating logics.
35
How Lisp Will Save the World
Biological models are complex webs of
parts, processes, dynamics, and operating logics.
The expressions in these models range over both
qualitative and quantitative value spaces.
36
Prochlorococcus
Only 1700 Genes!
37
ß-arrestins in GPCR Desensitization
38
Both!
Qualitative Quantitative
39
Causal/Regulatory Model

-
NBLA
NBLR
PBS

-
DFR
Health
psbA1

-
-

-

RR
Photosyntheticactivity
psbA2

-
Light
cpcB
Shrager, et al. (2002)
40
little b, aneil mallavarapu
41
http//qr05.tugraz.at/files/p18.pdf
42
(No Transcript)
43
(No Transcript)
44
ß-arrestins in GPCR Desensitization
45
How Lisp Will Save the World
Biological models are complex webs of
parts, processes, dynamics, and operating logics.
The expressions in these models range over both
qualitative and quantitative value spaces.
46
Prochlorococcus
Only 1700 Genes!
47
Biologists base their theories about what
something does upon whatother biologists think
some otherthings that look similar do.
48
Homology of hexokinase across species
www.bio.davidson.edu/Biology
49
High-Resolution Solution of a Potassium Channel
www.pdb.org
50
High-Resolution Solution of a Potassium Channel
www.pdb.org
51
Biologists base their theories about what
something does upon whatother biologists think
some otherthings that look similar do.
52
Cyanobacteria
http//www.anselm.edu/homepage/jpitocch/genbios/27
-11x1-Cyanobacteria.jpg
53
?
54
The Fiction of Function
55
Gene Ontology
From GenNav, the NIH Gene Ontology Browser
56
View Application
Transport
Ions
pH gradient driven ion Transport phosphorylation
pH Gradient
Phosphorylation
57
How Lisp Will Save the World
Biological models are complex webs of
parts, processes, dynamics, and operating logics.
The expressions in these models range over both
qualitative and quantitative value spaces.
Creating such models requires being able
tocompare and combine submodels.
58
How Lisp Will Save the World
Biological models are complex webs of
parts, processes, dynamics, and operating logics.
The expressions in these models range over both
qualitative and quantitative value spaces.
Creating such models requires being able
tocompare and combine submodels.
Each of these Demands Symbolic Computing
59
Prochlorococcus
60
PhotoSynthesis (light reactions)
Photosynthesis The Turing Test of biological
knowledge representation
http//www.bio.ic.ac.uk/research/barber/photosyste
mII.html
61
Where Prochlorococcus Go The BioSphere Follows!
Chlorophyll loading (NASA)