Case studies

1
Case studies

• Subjects measured with Arteriograph

2

• The scope of the Arteriograph
• Screening asymptomatic, apparently healthy
  subjects
• It makes possible to detect atherosclerosis in an
  early phase
• Evaluating the efficiency of applied therapy
• Follow-up
• Comparison

3

1. Screening asymptomatic, apparently healthy
   subjects

4
The data show low risk the subject is presumed
to be healthy, no intervention is needed
(according to guidelines) !!!
However, according to arterial stiffness
evaluation with Arteriograph...
5

• Examination
• High cholesterol level (7,30 mmol/l) was
  determined
• Conclusion
• By screening a low-risk, apparently healthy
  subject with Arteriograph risk of endothel
  disfunction could be showed
• Therefore the screening of asymptomatic subject
  with Arteriograph is needed and important !!!

6
However according to arterial stiffness
evaluation with Arteriograph...
7

• Examination
• Carotid Ultrasound positive (plaque)
• Conclusion
• By screening an apparently healthy subject with
  Arteriograph high CV risk could be showed
• Further examination (CUS) confirmed the necessity
  of treatment

8

• Evaluating the efficiency
• of applied therapy

9
First example
Treated (ß-blocker) hypertensive subject
However
Abnormal Aix, high central blood pressure
(Increased peripheral vasoconstriction!)
Use a ß-blocker, with vasodilation effect !!!
10
First example
The same subject with modified therapy
ß-blocker with vasodilation effect
Normal Aix, normal central blood pressure !!!
11
Second example
Treated (ß-blocker) hypertensive subject
Abnormal Aix, high central blood pressure
(Increased peripheral vasoconstriction!)
What are we supposed to do??? Rethink the
treatment!!! (Change therapy!)
12
Second example
The suggested new medicine is a CCB
Normal Aix, improved central systolic blood
pressure !!!
13

• Conclusion
• When treating a hypertensive subject, it is very
  important to lower - besides the peripheral BP -
  the central blood pressure as well !!!
• The Arteriograph gives important hemodynamical
  parameters by which the effect of an
  anti-hypertensive drug can be evaluated

14
A study ???
Post-MI, post-PTCA subject

• Which one is good prognosis
• high Aix, or
• low Aix
• ????????????