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• ?????????????????????
• 1918?????(H1N1??A?,???????)
• H5N1?????
• SARS??
• ????????????????

3
???????? (??238)
Virus
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??????? (??-246)
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??????????? ( RNA / DNA )
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DNA????? (??027)
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RNA????? (??027)
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????? H5N-1 ??
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10
?????

• HA????????????????,?NA??????????????????
• ?????HA?NA????????
• ????????HA?NA??????????
• A?????,?16?H???9?N???
• 1968??????,????A(H3N2)

11
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12
????????

• ??????????????????????????(Shift),???????????(drif
  t)?
• ??????????????????????????????
• ???????????????
• ?????????????,??????????
• ???????????????(PANDEMICS)
• 1918 (killer flu) A(H1N1)? 4,000????
• 1957(Asian flu) A(H2N2) ?7??????
• 1968(Hong Kong flu) A(H3N2)? 5, 000??????,7?????

13
1918??????? (??212)
Courtesy of the National Museum of Health and
Medicine, Armed Forces Institute of Pathology,
Washington, D.C., United States.
14
??????
????? Ann H. Reid and Jeffery K. Taubenberger.
The origin of the 1918 pandemic influenza virus
acontinuing enigma. Journal of General Virology
(2003), 84, 22852292
15
1918?????

• 1918-1919???????????,??????,????????????,???????
• ???????????????????????????????1918???????????????
  ????,????????
• ???????????????????,??????????????????????????????
  ,??????????????????????????????????????,????????!

16
???????-?2004?H5N1???????
 ?  Countries with poultry or wild birds killed by H5N1.
 ?  Countries with humans, poultry and wild birds killed by H5N1.
WHO Confirmed Human Cases of H5N1
Created with OpenOffice Calc
17
?????????? (??142)
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18
??????????? (??113)
Hanoi by SPOT Satellite
19
???????? (??155)
20
?????????????(??243)
21
???????????

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22
SARS

• 2003?????????SARS??????
• ??????,71????
• ?????????
• ???SARS??????????????????????????????????????????
  ??????,???????????

23
???????????????????????,????????SARS??,???????????
???

• ??2005/9/29??????,???????????4??????SARS???????,
  ?????????????70?????????,????????????????????????
  ??????SARS?????SARS???????92,??????????????SARS??
  ??????????????
• ????????????????????????????????????????,????????
  ????????),?????????,????????

24
????????????? (??1'56)
25
????

• Neil A. Campbell, Jane B. Reece, Lisa A. Urry,
  Michael L. Cain, Steven A. Wasserman, Peter V.
  Minorsky, Robert B. Jackson (2008). Biology .
  Eighth edition.Chapter 19.page381393. San
  Francisco Benjamin Cummings.
• Peter H. Raven, George B. Johnson (2002).
  Biology. 6th edition, Chapter 19. Boston Burr
  Ridge McGraw Hill.
• James Stevens, Adam L. Corper, Christopher F.
  Basler, Jeffery K. Taubenberger, Peter Palese,
  Ian A. Wilson. Structure of the Uncleaved Human
  H1 Hemagglutinin from the Extinct 1918 infleuenza
  Virus. Science (2004) 3031866-1870
• Ann H. Reid and Jeffery K. Taubenberger. The
  origin of the 1918 pandemic influenza virus
  acontinuing enigma. Journal of General Virology
  (2003), 84, 22852292
• Keisuke Okita, Tomoko Ichisaka Shinya Yamanaka.
  Generation of germline-competent induced
  pluripotent stem cells. Nature 448, 313-317.

Page 25
26
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• DISCOVERY VIDEO UnderstandingViruses
  (????),????
• Discovery,???????
• ?????????????2-??????
• ??NHK92/05/23??SARS????????,90???
• ??NHK92/10/06???SARS????????????,24???
• ??NHK, (2/04/2004) ??????????????,???????????????
  

Page 26
27
???3-1
28
???3-2
29
???3-3
30
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• GNU Free Documentation License, Version 1.2 or
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  Foundation
• ????????GNU Free Documentation License, Version
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• WIKI -This image has been (or is hereby) released
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31
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