1 ??????Qa?

1
???????????

• ??????????

2
???? ????

• 1 ??????Qa?
• 1.1 ????????
• ?????????
• ????????????????????????,??12?????

3
1.1 ????????

• 1.1.1 ???????
• ?????????(????)
• 1.1.2 ?????
• ??????(????)
• 1.1.3 ????
• ?????????(????)
• 1.1.4 ????
• ????????????(????)

4
1.1 ????????

• 1.1.5 ????
• ????
• ????
• ????
• ?????(Prescribing Information)
• ????(Monography)
• ?????
• ????
• ??????(MSDS)(????)

5
1.1 ????????

• 1.1.6 ????
• ??????????????(????)
• 1.1.7 ????
• ?????????(????)
• 1.1.8 ????
• ???????????(????)
• 1.1.9 ??
• ???????????(????)

6
1.1 ????????

• 1.1.10 ??
• ???????????(????)
• 1.1.11 ??
• ????????????????(????)
• 1.1.12 ????????
• ???? ? ???? ? ????
• ???????????????????????12?????????,???
  ?????????

7
1.2 ???????????

• 1.2.1 ??????
• 1.2.2 ??????
• ?????????????????????,????????????????

8
1.3 ???????????
???????????????,????,?????
9
2 ????????

• ????(Ghemical Name)
• ????(Trade Name)
• ????(Generic Name)
• ???????(International Nonproprietary Name, INN)
• ????????
• ????
• CAS???

10
2.1 ????(Chemical Name)

• Common Name
• p-isobutyl-hydratropic acid
• ?-????????
• Systemic Name(IUPAC)
• ()-2-(4-isobutylphenyl)propionic acid
• ??-2-(4-????)??
• CAS Name
• Benzeneacetic acid, a-methyl-4-(2-methylpropyl)
  -
• a-??-4-(2-????)???

11
2.2 ????(Trade Name)

• Advil brufen Ibufen Motrin Nuprin
  Nurofen Paduden Proflex Rufin Unipron

12
2.3 ????(Generic Name)

• USAN(United States Adopted Names)
• BAN(British Approved Names)
• JAN(Japanese Accepted Names)
• NFN(Names Approved by the Nordic Pharmacopoeia
  Council)
• Ibuprofen

13
2.4 ???????

• WHO?????????,????????,?????????,???????
  ???
• (International Nonproprietary Names for
  Pharmaceutical Substances,??INN)?
• 1953?????????????,??????,????????????,??
  ???????????????????????INN?????INN??????,????,????
  ????

14
2.4 ???????

• ?WHO??,???????,???????INN???????????,??
  ?????????????,WHO????INN(Proposde
  INN)????,??????,??????????,?????INN
• (Recommedded INN)????,?????????,??????????????????
  ????????????,??????INN?

15
2.5 ????????

• ????????(Chinese Approved Drug
  Names,??CADN)?CADN????????????????????????????
• ???

16
2.6 ????

• RD-13621
• U-18573
• ATC-3

17
2.7 CAS???

• IUPAC?????
• CAS??
• 15687-27-1

18
3 ?????????

• ????(??????)
• ????(??????)
• ????(????)
• ????(????)
• ????(???)
• ????(???)

19
4 ?????????

• INTERNET (???)
• WWW(???)
• HTTP(???????)
• URL(???????)
• HTML(???????)
• WWW Browsers(WWW ???)
• FTP(??????)
• E-mail(????)
• Proxy Cache(????????)

20
4.1 INTERNET (???)

• INTERNET??????????????,???TCP/IP??????,???????????
  ???????????????????,?????????????????,????????
  ?????
• ??????????????,??????????????
• ???????????,???????????????????????????
• ??????????????????/?????????

21
4.2 WWW(???)

• WWW?World Wide Web??????World Wide
  Web,???Web????????,?????????,???????????????,W
  WW?????????
• WWW??????????????????????????????????????????,????
  ????(????????????????????)??????????,?????????????
  ?WWW????????,??????????????
• ?WWW????,?????????????????????????,?WWW???????????
  ???

22
4.3 HTTP(???????)

• HTTP?HyperText Transport Protocol
  ????????????????????
• HTTP????????(WWW)??????????
• ?????WWW??????????,????????(????)??????????,??????
  ???????????HTTP???????????????,?????????????????
  ???????????

23
4.4 URL(???????)

• URL? Uniform Resource Locator ???????????????????
  ?
• URL??Internet??????,??????Internet????????????????
  ?????????????,????Internet????????????
• URL?????,?????????????????????,????????????(?IP??
  )?????????????
• ?

24
4.4 URL(???????)

• ????
• ../home.htm
• ???????????????
• ???? http//lib.hebust.edu.cn/zxtg/001.htm ?
  http//202.206.73.60/zxtg/001.htm
• URL??????www?????,??????FTP?Gopher?WAIS?Uesnet
  News?Telnet??????????

25
4.5 HTML(???????)

• HTML ? HyperText Markup Language
  ????????????????????
• HTML???????????WWW?????????,???????(SGML)???,?????
  ?????????????????????
• HTML????????????,???WWW??????,????????????,???????
  ?????,?????????????(?Internet Explorer)????

26
4.6 WWW Browsers

• WWW ???? WWW ??????,???? WWW ?????????????????
• ????????????? (NCSA) ?1993???? Mosaic ????? WWW
  ???,??? WWW ???????????,??????????????
• ???????????????????(Netscape Navigator)????????
  ?(Internet Explorer,??IE)?
• ????? IE ? WINDOWS ???????????? WINDOWS
  ?????,?????? IE?

27
4.7 FTP(??????)

• FTP ? File Transfer Protocol ???????????????????
  
• ????????FTP,?????FTP????????????????Internet?????F
  TP????????????ASCII????????????
• Anonymous FTP ?????? FTP ????,? Anonymous
  ?????,?????????????,???????????FTP??????

28
4.8 E-mail(????)

• E-mail ? electronic mail ?????????????????
• ??????????????????????????????????????????????,???
  ???????FTP??? E-mail Alerts ??????????????????????
  ??????

29
4.9 Proxy Cache

• ?????????
• ??????????Proxy Server, ????Proxy ?
• ??????????
• ?????????,?????
• b) ??IP??
• ???????

30
4.9 Proxy Cache

• ??????????
• ?????????????,CERNET????????,??????????????????
  
• ??????????IP????????? ?

31
4.9 Proxy Cache

• ??????????
• ????????????????
• ???????BBS????
• ??????????????
• ????????????????????????

32
4.9 Proxy Cache

• ProxyHunter????????????
• ??????????,???????????????IP????????,????????????
  ??,?????????????????????????????(PROXYHUNTER)????
  
• a) ??b) ??c) ??d) ??e) ??f) ??g) ????????

33
5 ???????????

• ???? (URL's List)
• ???? (Gate Sites)
• ???? (Search Engine)
• ????? (Online Databases)
• ???? (Online Glossary)
• ????????

34
5.1 ???? (URL's List)

• ??/??? (Links)
• HTML??????????lta href"URL"gt????lt/agt,??,?HTML?????
  ????
• lta href"http//202.206.73.60/"gt?????????lt/agt
• ??,?WWW??????,?????????
• ?????????
• ?????????????,??????URLs List?
• ???????????,???????????????URL's
  List,??????????????????????URL's
  List,???????????

35
5.1 ???? (URL's List)

• ??/????? (Navigation)
• ???URLs List,?????????????,???????
  ???????,???????,??????????
• ?????????,??????????,?????????????

36
5.1 ???? (URL's List)

• ????? (Virtual Libraries)
• ??????????????????,??????????????????,?
  ?????????????????URL's List,???????????????
• ????????,?????????????300??????????????
  ????????URL?http//vlib.org/ ????????????????????,
  ?????????

37
5.1 ???? (URL's List)

• ????? (Virtual Libraries)
• ????????????????URL???
• 1)???? http//www.cato.com/biotech/
• 2)???? http//www.che.ufl.edu/www-che/
• 3)? ? http//www.liv.ac.uk/Chemistry/Links/
• 4)? ? http//www.pharmacy.org/

38
5.2 ???? (Gate Sites)

• ????,?????????????(ISP)???????,?
• ?? http//www.yahoo.com
• ?? http//www.sohu.com
• ?? http//www.sina.com.cn ??
• ????,??????????????????????,??????????,??????????,
  ???????????????

39
5.2 ???? (Gate Sites)

• ?????????????????????,???????,????,?????????????,?
  ?????,?????????????????
• ????????????????????IE???,?????,?????????????,????
  ?????IE??????
• ??----Internet??----?????

40
5.3 ???? (Search Engine)

• ??????? ?
• ?????????
• ???????
• ?????????????????
• ???????
• ????????????

41
5.3 ???? (Search Engine)

• ??????? ?
• ????(Search Engine)????????????????????
  ??????????
• ????????
• ?? http//www.sohu.com ?? http//www.sina.com.c
  n
• ?? http//www.yeah.net ?? http//e.pku.edu.cn
  
• Yahoo! http//www.yahoo.com/ Google
  http//www.google.com

42
5.3 ???? (Search Engine)

• ???????
• 1)????????????
• 2)????????????????
• 3)????????????
• 4)??????????,???????????
• 5)??,??????????????????????

43
5.4 ????? (Online Databases)

• ???????????????????????????????
• ????????,??????????????????????
• ???????,???????????????????????
• ?????????,???????????????????
• ??????????,?????????????????????

44
5.4 ????? (Online Databases)

• ??????????????,?????????,??????????
• ?????????? http//www.nstl.gov.cn/
• ??????? http//www.sdb.ac.cn
• ??????????????? http//202.127.145.134

45
5.5 ???? (Online Glossary)

• ??? 21
  http//www.chemicalland21.com/
• ??????? http//www.hclrss.de
  mon.co.uk/

46
5.6 ????????

• ???????? http//www.cnki.net
• ???????????? http//61.186.190.10380
  80/
• (????test ??test)

47
6 ??????

• Internet Explorer (IE)
• WinRAR
• Netants
• Foxmail
• Acrobat Reader
• Alterna TIFF
• ???????
• Chemoffice

48
6.1 Internet Explorer (IE)

• Internet Explorer,?????IE,?Microsoft??????? WWW
  ???????????? Internet Explorer,??????? Web
  ???????
• ????????????Internet Explorer 6.0(?????)??????????
  ??????IE?????,???????windowsupdate.microsoft.com??
  ?????
• Internet Explorer??????????,???,????????????????
  ??????

49
6.2 WinRAR

• WinRAR ????
• WinRAR?32? Windows ??? RAR ????????
• WinRAR ??
• 1)???? RAR ? ZIP ????
• 2)??????? (??????)
• ????http//www.winrar.com.cn/

50
6.3 Netants

• NetAnts???????,????,??????????????????,??????
  ??????? ?
• ????????????NetAnts 1.25(?????)????????????????Net
  Ants?????,???
• http//www.netants.com???????
• ?????????,???????????

51
6.4 Foxmail

• Foxmail ???????????????,????? Internet ???????
• ?????????????WebMail??(??????)????????????????????
  ?,?????????????,????????????????????????????????,
  ?????????????????????????????????????,????????????
  ??????????????
• ???? http//www.foxmail.
  com.cn

52
6.5 Acrobat Reader

• Acrobat Reader ?Adobe????????????,??????PDF?????
• ?????????,??????????????????,????????,???PDF??????
  ??,??????????????? Acrobat Reader
  ??,?????PDF???????????????
• ?Acrobat PDFWriter??????????????PDF????????PDF???
  ?????

53
6.6 Alterna TIFF

• ????????????????????????????????,????????TIFF?????
  ??,????????????? Alterna TIFF ??,?????TIFF????????
  ???????
• TIFF????????
• http//www.alternatiff.com/install/

54
6.7 ???????

• ????????????,??????????,????????????????,???????
  ?,????????????,???????????
• ??,????????????????,?????????CAJ???,????????????
  ??,?????????NLC???......?

55
6.8 Chemoffice

• ChemOffice Ultra 2004???
• ChemDraw Ultra 8.0??????
• Chem3D Ultra 8.0???????
• ChemFinder Pro 8.0??????????
• ???????????Chemoffice Ultra 8.03
• Serial 7654321
• key VLPG-CG5O-5K22-VKVK-RF

56
???? ????

• 7 ?????????
• 7.1 ?????????????
• 7.2 ???? (Online Glossary)???

57
7.1 ??????????

• CRC ???????http//www.hbcpnetbase.com/ (?????7?)
  
• Kirk-Othmer ??????http//www.mrw.interscience.wil
  ey.com/kirk/ (???????)
• HPLC??????http//hplc.chem.shu.edu/NEW/HPLC_Book/
  index.html
• NMR??????http//www.cis.rit.edu/htbooks/nmr/
• National Academy Press,Read Books Online Free
  http//www.nap.edu/about/availpdf.phtml
• 500????????????http//fb4d.com/
• ????????????http//www.amedeo.com/

58
7.2 ???? (Online Glossary)

• ??? 21 http//www.chemicalland21.com/
• ?????????,????????,?????????????????,??
  ??????PRODUCT IDENTIFICATION?PHYSICAL AND
  CHEMICAL PROPERTIES?GENERAL DESCRIPTION
  APPLICATIONS?SALES SPECIFICATION?TRANSPORTATION?OT
  HER INFORMATION?,?????????????????????????????????
  ?

59
7.2 ???? (Online Glossary)

• ??????? http//www.hclrss.demon.co.uk/
• ???????,?????????URL? http//www.alanwood
  .net/pesticides/
• ??32????1400?????????????????????ISO????
  ??????ISO??????????,2-3???????????

60
7.3 ?????????

• ???????????
• ??http//www.cnki.net???????
• ????????????
• ????????
• ?http//www.google.com ????????????????
• Keywords pyruvate, comprehensive, review

61
8 ??????

• 8.1 ????????
• 8.2 ????????
• 8.3 ?????EPO?????????
• 8.4 ????????WIPO?????????
• 8.5 ?????JPO?????????(???)

62
8.1 ????????

• ?????????????? http//www.sipo.gov.cn/sipo
  /zljs/default.htm
• ????TIF????,????????????,????????
  ??????????????(http//www.alternatiff.com/install/
  )
• ?????????
• ?????????TIF????????

63
???????16?????,????
64
8.2 ????????????

• ???????USPTO????????? http//www.uspto.gov/patf
  t/index.html
• Issued Patents (PatFT) 1790??????????????????????
  ,??,1976????????????????
• Published Applications (AppFT) 2001?3?15???????(?
  ??)??????????????,??????????(??)???

65
8.2 ????????????

• Quick Search??????????????????
• Advanced Search?????????????????????
• Patent Number Search???????,????????????

66
8.2 ????????????

• ????????????????????????????????Search
• 1976 to present full text
• 1790 to present entiredatabase
• 1790 to 1975 PN and CCL only
• Patents from 1790 through 1975 are searchable
  only by Patent Number and Current US
  Classification!

67
8.2 ????????????

• ?Query ??????????????????????Search
• ?????????
• TTL/(glyoxylic AND (production OR preparation OR
  manufacture) ANDNOT (derivatives OR ester OR
  esters))

68
8.2 ????????????

• ?????????

69
8.2 ????????????

• ???????(??)

??? ??? ??? ???
PN ??? CCL ???????
ISD ??? ICL ???????
TTL ???? APN ?????
ABST ?? APD ???
ACLM ???? IN ???
SPEC ???? AN ???
70
8.2 ?????????????

• ?Query??????,???
• 1)???????????
• 2)????????
• 3)????????
• ?????2?????
• 1)1975????????
• 2)1976?????????

71
8.2 ?????????????

• ?????(Full text)?????????????????,??????????,????
  HTML??????????????????????????,?????????????????
  ?????????
• ???????????????,???????????Images???????full
  text?Images????????????????TIF?????(??????????????
  ??)?

72
8.3 ????????????

• ?????URLhttp//ep.espacenet.com/
• ??19????????????????,?????????????(???)??,????????
  ????????
• ?????????????,URL???????????????,?
• ?? gb?? fr??? es???? cy?? ch
  ????????????????????,???????
• ?Acrobat Reader???????????

73
8.3 ????????????

• ??4???????????
• Quick Search ??????????????
• Advanced Search???????????????,????????????
• Number Search???????????????????????????
• Classification Search????????????

74
8.4 WIPO?????????

• ?????URLhttp//www.wipo.int/
• ??1997?1????????PCT???????????
• 1997?1?????????????????????????worldwide?????
• ??????,????,???????????
• ????????(??)?????????????,???????14????????

75
8.5 JPO???????(???)

• ?????URLhttp//www.ipdl.jpo.go.jp/homepg_e.ipdl
• ??1976?10???????????????(?????????)?????
• ??1993???????????????????

76
9 ????????????

• 9.1 ?????????????
• 9.2 ???????????
• 9.3 ???????????

77
9.1 ?????????????

• ?? http//www.nstl.gov.cn
• ???????17,824,313?,??
• ?????????? (503135?)??????? (592084?)?????
  (6238189?)??????? (21187?)???????? (1708?)
• ?????????? (2355829?) ????? (6879242?)???????
  (784184?)??????? (74335?)????? (109216?)
• ??????????? (183136?)????? (82068?)

78
9.1 ?????????????

• ????
• ?????????????????????????????????(??????
  ????)??????????????????
• ????,????????
• http//www.nstl.gov.cn

79
9.2 ????????

• ?? http//www.cnki.net
• ??
• ???????????CNKI??????????152?,??????,??
  ??????????
• ??
• ?????????????????
• ???????????????,????????,??????,?????
  ??????
• ?????????????????????????????????
  ????????????) ?????????????????

80
9.3 ???????????

• ChemWeb.com Quick Abstract Search
  http//www.chemweb.com/abstracts/
• ??Elsevier?Kluwer?Marcel
  Dekker?????????????310?,?????,??????
• National Library of Medicines Medline and
  Premedline Databases
• http//www.medportal.com/

81
9.3 ???????????

• 1400????????? http//www.freemedicaljournals.com
  
• ???????? http//www.pubmedcentral.nih.gov/about/b
  mcjournals.html
• ????,??????????????????????????????????
  ?????,???????????????,??????????????????????????,?
  ???????????

82
10 ??????????

• ??????????????? http//202.127.145.134
• ???????????,????????????

83
10.1 ????????

• ????????http//202.127.145.134/ssdb/str/str_full_q
  uery.asp
• ??????????????????????????????????
• ?????????
• http//202.127.145.134/ssdb/str/str_pro_query.
  asp
• ????????????CA??????????????????????????
  ?

84
10.2 ?????????

• ???????? http//202.127.145.134/ssdb/crc/str_full
  _query.asp
• ???????????????????
• ????????
• http//202.127.145.134/ssdb/crc/crc_query.asp
• ???????,????????

85
10.3 ?????????

• 1) ???????
• http//202.127.145.134/ssdb/irs/irs_p
  ro_query.asp
• ?????????????CA???????????
• 2) ????
• http//202.127.145.134/ssdb/irs/ir_upl
  oad.asp
• ???????????(prn,asc??)?????????????nyy
  ??,?????????????????????

86
10.4 ????XIV???????

• ??-??????
• http//jpdb.nihs.go.jp/jp14e/ultraviolet_spect
  ra.html
• ??????
• http//jpdb.nihs.go.jp/jp14e/infrared_spectra.
  html

87
11 ???????????

• 11.1 ????
• ???????? http//www.qualityinfo.com.cn/GN.asp
• ??????(?????????????)?????(???????????
  ????ISO??)???????????????????
• 11.2 ??????(MSDS)??
• MSDS Databases http//www.msdssearch.com/DB
  LinksN.htm

88
12 ????

• ????????????
• http//ccn.mofcom.gov.cn/
• ?????????? http//www.chemol.com.cn/linktoywlk/pc
  hinasearch.asp
• ????????? http//www.chemsina.com8768/pecbusines
  s/defaultshow.asp
• ????????? http//www.chemsina.com8768/dailynews/
  c/defaultshow.asp
• ????????
• http//www.wanfangdata.com.cn/

89
13 Merck Index ?????

• 12.1 Merck Index 13th
• http//themerckindex.cambridgesoft.com
  /
• ???????,?????14??
• 12.2 ?ChemFinder?Merck Index???????
• http//chemfinder.cambridgesoft.com/

90
14 ??????

• ?????google?????,
• ? Pyruvate fy ? search, ????
• pyruvate ????
• ? pyruvate review comprehensive
  ????????,???????PYRUVATE A COMPREHENSIVE
  REVIEW(C)1997??13?????????????

91
14 ??????

• ? pyruvate pdf MSDS ????????,??Sodium Pyruvate
  Solution ?PDF???MSDS???
• ? biochemistry ppt ????????,??????????????????
• ? Roche annual report????????,??????1999-2004?????
  ??

92
???google???????1?

• ?vitamin b12 and HPLC and fermentation??????,??w
  ww.nstl.gov.cn/?????????,?????????????Determinati
  on of vitamin B12 in multivitamin tablets and
  fermentation medium by high-performance liquid
  chromatography with fluorescence detection.
  Journal of Chromatography.891(2),243-247(2000)

93
???google???????1?

• ???????????,??www.google.com??????,??????????,????
  ??????????web.hku.hk/sfchen/????????56??????????
  ?E-mail??sfchen_at_hkusua.hku.hk

94
???google???????1?

• ??????????????,????????,??????????PDF????,?5??
• ??!