Mechanism of Insulin Secretion by ?-cells

1
Mechanism of Insulin Secretion by ?-cells
ROLE OF THE KATP CHANNEL
2
NO KATP CHANNEL ACTIVITY, MEMBRANE DEPOLARIZATION
AND HIGHER Ca2i IN PANCREATIC Kir6.2-/- ß-CELLS
3
GLUCOSE AND TOLBUTAMIDE NO LONGER STIMUALTE
INCREASES IN Ca2i IN Kir6.2-/- ß-CELLS
4
GLUCOSE NO LONGER STIMULATE INSULIN SECRETION IN
Kir6.2-/- ß-CELLS
5
NEAR NORMAL GLUCOSE TOLERANCE AND INCREASED
INSULIN SENSITIVITY IN Kir6.2-/- MICE
6
INFILTRATION OF a-CELLS IN THE MIDDLE OF THE
Kir6.2-/- PANCREATIC ISLETS
7
(No Transcript)
8
(No Transcript)
9
(No Transcript)
10
(No Transcript)
11
(No Transcript)
12
(No Transcript)
13
(No Transcript)