Coenzyme A

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Coenzyme A
Pantothenate
2-mercaptoethylamine
ADP
Acyl carrier protein
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Fritz Lipmann
Noble prize for Chemistry 1953 (shared with Sir
Hans Krebs)
"for his discovery of co-enzyme A and its
importance for intermediary metabolism"
1899-1986
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Pyruvate dehydrogenase

• The core of the complex consists of 60 copies of
  E2.
• At the periphery of the complex are
• 30 copies of E1 (itself a tetramer with subunits
  a2b2)
• 12 copies of E3 (a homodimer), plus 12 copies of
  an
• E3 binding protein that links E3 to E2.

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Pyruvate dehydrogenase
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Regulation of PDH
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Sir Hans Krebs Noble Prize for Chemistry
"for his discovery of the citric acid cycle"
1900 - 1981
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or GTP
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Make a couple of copies of this for class
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Biotin
CO2