???????S???

1
???????S???

• ???????? ????????
• ??????S ?????????S
• ???S????????S S????G???S ???????????????G???S
  ??????S
• G ??????????? ??????? ??T

2

• ??? pa?eµß?se?? e??a? t? µe?a??te?? ep?pt?s? st?
  d?µ?s?a ??e?a d?e????
• ?? ?a?a?? ?e?? ?a? ta ?µß???a

?a???sµ?a ??????s? ??e?a?
3
?µß???a

• ?a eµß???a s???ata?????ta? sta ep?t???ste?a µ?sa
  po? d?at??e?ta? ??a t?? p?????? t?? ?os???t?ta?.
• p?ostate???? t? eµß???a??µe?o ?t?µo ap? t?
  d???t??? a??pt??? s?ßa??? ?o?µ?d?? ?os?µ?t?? ?a?
• µe?????? t? d?aspo?? t?? ???µ??e?? st?? e???te??
  ?o???t?ta µe to µ??a??sµ? t?? s????????? a?os?a?.

4
???????S???

• ?e???t? e?e???t??? a??s?a eµß???asµ??
• F?s??? e?e???t??? a??s?a ??s?s?
• ?a??t??? a??s?a a??s?sfa????e?

5
????G????? ???S?????S?

• ??e???t??? a??s?p???s? (eµß???asµ??) e??a? ?
  ??????s? e??? eµß????? µe s??p? t?? p?????s?
  e?d???? a??s???????? ap??t?s?? (??µ???? ?
  ??tta?????), µe pa???aµ?? t?? ???d???? p??
  ape????? t? ep???s? ?t?µ? ap? t? f?s??? ??s?s?.

6
(No Transcript)
7
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8
?a eµß???a µp??e? ?a pe???????

• ???te? e?as?e??µ????? (attenuated) pa????????
  µ???????a??sµ???, ?p?? s?µßa??e? µe p???? eµß???a
  ??a?t? ??? (p.?. ??a???, e??????, pa??t?t?da?,
  a?eµe???????, t? eµß???? Sabin ??a t??
  p????µ?e??t?da ?a? t?? ??t????? p??et??), t? ap?
  t?? st?µat?? ???????µe?? eµß???? t?? t?f?e?d?
  p??et?? ?a? t? eµß???? ?at? t?? f?µat??s?? (BCG).

9

• ?d?a??p???µ?????(killed//inactivated)???µ???????
  pa?????te?, ?p?? s?µßa??e? µe a??et??? ???? ?a?
  ta pe??ss?te?a ßa?t???d?a (p.?. eµß???a ?????t?,
  ?pat?t?da? ?, ???pp??, ?????a?, ??ssa?,
  pa?e?te???? eµß???? t?f?e?d? p??et?? ?a? Salk
  ?at? t?? p????µ?e??t?da?).

10

• ???p?p???µ??a at????? p?????ta t?? pa???????
  µ???????a??sµ??, ?p?? s?µßa??e? µe ta t???e?d?
  (toxoids) p?? pe??????ta? sta eµß???a t??
  d?f?e??t?da? ?a? t?? tet????. ? d?at???s? ?µ??
  µa????????a? a??s?a? apa?te? pe???d???
  epa?a??????s? a?aµ??st???? d?se?? t?? eµß?????
  (boosters).

11

• ?µß???a p?? pe??????? tµ?µa t?? ???µ??????
  pa?????ta (eµß???a ?p?µ???d??, subunits), eµß???a
  p?? pe??????? s???et??? p???pept?d?a ? eµß???a
  p?? pa?????ta? µe te?????? a?as??d?asµ????
  (recombinant) DNA, ?p?? t? eµß???? t?? a?µ?f????
  ???pp?? t?p?? b, t?? ?pat?t?da? ?, t??
  µ??????t?d??????? ?µ?d?? C, t?? p?e?µ??????????
  (7-d??aµ? s??e??µ???) ?a? t? pa?e?te???? t??
  t?f?e?d? p??et??.

12
???s?a?? ap??t?s? se ap?? p???sa??a??d??? ?a?
s??e??µ??a p???sa??a??d??? eµß???a
13
?a eµß???a µp????? ?a d?a??????? ep?s?? se

• 1. ????d??aµa ?ta? pa?as?e?????ta? ap? ??a? µ???
  µ???????a??sµ?, tµ?µa ? t??p?p???µ??? p????? (p.?
  eµß???? ??a t?ta?? ? ?pat?t?da ?) ?a?
• 2. ????d??aµa ?ta? pa?as?e?????ta? ap?
  pe??ss?te?a e?d? µ???????a??sµ?? (p.? MMR) ?
  t??p?p???µ???? p?????t?? t??? ? ap? pe??ss?te????
  t?p??? e??? ???µ?????? pa?????ta (p.? OPV). ?a
  te?e?ta?a ap?te???? s?µe?a t? s??????? t?s? ??a
  t?? pa?a???? eµß????? ??a ß??f? ?a? pa?d??.

14
(No Transcript)
15
???a??? t?? te?e?ta?a? de?aet?a?

• ?fa?µ??? t?? p???d??aµ?? eµß?????
• ??t??at?stas? eµß????? (DTP DTaP, OPV
  IPV)
• ?a?????s? ???? eµß????? (µ??????t?d???????
  ????µ?d?? C, p?e?µ??????????, a?eµe???????, ?PV)
• ??tat???p???s? eµß???asµ?? t?? ef?ß??

16
????S ???????S???

• ?? eµß???asµ?? st??????ta? st? de?te???e??
  a?t?s?µat??? a?tap????s?.
• ? ap??t?s? t?? ???a??sµ?? µet? t?? epaf? µe
  ???st? a?t?????, ??e? ?? ap?t??esµa t?? ta??te??,
  se ?????te?? st??µ? ?a? p?? ap?te?esµat???
  pa?a???? a?t?s?µ?t??. (a??s??????? µ??µ?).
• G?a ta eµß???a µe ???te? e?as?e??µ?????
  µ???????a??sµ???, µ?a de?te?? d?s? t?? a?t??????
  e??a? ??a?? ?a ep??e? ??a??p???t??? a??s???????
  ap??t?s? (µe???? a?t??????? ?s???).

17
G?????S ????S ???????S?O?

• ?????a ??a???? ap? t? 2? µ??a t?? ????
  (e?a???se??).
• ?????st? µes?d??st?µa µeta?? t?? d?se?? 4
  eßd?µ?de? (e?a?t?ta? ap? t? e?d?? t?? eµß?????).
• ?aµ?a d?s? eµß????? de ???eta?.
• ?a?t?????? ??????s? eµß????? de? ep??e??e? t??
  a?t?s?µat??? ap??t?s?,??te a????e? t??
  a?ep???µ?te? e????e?e?.

18
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19
???G????? ???????S?O?
?????a ?µß???? G????s? 1 µ?? 2 µ??. 4 µ??. 6 µ??. 12 µ??. 12 µ??. 15µ??. 15µ??. 18 µ??. 24 µ??. 4-6 et. 11-12 et 11-12 et 13-18 et.
?pat?t?da? ?(Hep B) Hep B Hep B (1-2 d?se??) Hep B (1-2 d?se??) Hep B Hep B Hep B Hep B Hep B Hep B
?pat?t?da? ?(Hep B) Hep B Hep B Hep B Hep B Hep B Hep B Hep B Hep B Hep B (??e? ?? d?se??) Hep B (??e? ?? d?se??) Hep B (??e? ?? d?se??) Hep B (??e? ?? d?se??) Hep B (??e? ?? d?se??)
??f?e??t?da?,?et???? ?????t?(DTaP) DTaP DTaP DTaP DTaP DTaP DTaP DTaP DTaP Td(1 d?s? a?? 10et?a) Td(1 d?s? a?? 10et?a) Td(1 d?s? a?? 10et?a)
?????µ?e??t?da? IPV IPV IPV IPV IPV IPV IPV IPV IPV IPV IPV
??µ?f???? t?p?? ? Hib Hib Hib Hib Hib Hib Hib
???????t?d??????? C (MCC) MCC MCC MCC MCC MCC MCC MCC MCC MCC MCC MCC
??e?µ?????????? (PCV) PCV PCV PCV PCV PCV PCV PCV PCV PCV (PPV) PCV (PPV) PCV (PPV) PCV (PPV) PCV (PPV)
??a???,?a??t?t?da?, ??????? (MMR) MMR MMR MMR MMR MMR
??eµe?????a? (Var) Var Var Var Var (2 d?se??)
F?µat??s?? (BCG) Mantoux Mantoux Mantoux BCG Mantoux BCG Mantoux BCG Mantoux BCG Mantoux BCG Mantoux BCG
20
?a?d?? ?????a? ??? 7 et?? p?? ?a??st???sa? ?a
eµß???as????
1? d?s? 2? d?s? 3? d?s? 4? d?s? 5? d?s?
??????? ?µe??µ???a 1?-2? d?s? ?µe??µ???a 2?-3? d?s? ?µe??µ???a 3?-4? d?s? ?µe??µ???a 4?-5? d?s? ?µe??µ???a
?pat?t?da? ?(Hep B) 4 eßd. 3 µ??
??f?e??t?da?-tet????-?????t? (DTaP) 4 eßd. 4 eßd 6 µ?? 6 µ??
?????µ?e??t?d?? IPV 4eßd. 4 eßd 4 eßd
??µ?f???? t?p?? ß(???) 4eßd. 4 eßd 8 eßd
???????t?d??????? C(MCC) 4 eßd. 4 eßd 8 eßd
??e?µ??????????(7d??aµ?)(PCV) 4 eßd. 4 eßd 8 eßd
??a???-pa??t?t?d??-e?????? (MMR) 4 eßd.
??eµe?????a?(Var)
F?µat??s??(BCG)
F?µat???a?t?d?as?(Mantoux)
?pat?t?d?? ?(Hep A) 6 µ??
G??pp??(INFL) 4 eßd
21
?a?d?? 7-18 et?? p?? ?a??st???sa? ?a
eµß???as????
?µß???? 1? d?s? ?µe??µ???a 1?-2? d?s? 2? d?s? ?µe??µ???a 2?-3? d?s? 3? d?s? ?µe??µ???a 3?-4? d?s? 4? d?s? ?µe??µ???a
?pat?t?da? ?(Hep B) 4eßd 3µ??
??f?e??t?da? ,?et????(Td) 4eßd 6µ?? 6µ??
?????µ?e??t?da? IPV 4eßd 4eßd 6µ??
???????t?d??????? C(MCC)
??a???,?a??t?t?d??,???????(MMR) 4eßd
??eµe?????a?(Var) 4eßd
?pat?t?d?? ?(Hep A) 6µ??
G??pp??(INFL)
22
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23
S?????S???? ???????

• DTaP
• DTaP IPV
• DTaP IPV Hib
• DTaP IPV HBV
• DTaP IPV HBV Hib
• DTaP HBV
• ??? ????G?????? ???? ??? 6? ??????? ??S ?O?S

24
??????? ?ep B ??????S ??????OS??S

• ?ta? ? µ?t??a e??a? f???a? t?? ??sAg,?
  eµß???asµ?? ???eta? aµ?s?? µet? t? ?????s?.
• ?a??????a, se a?t? t?? pe??pt?s? ????????ta? 0,5
  ml ?pe????s?? sfa??????, se d?af??et??? ??s?.
• ?? ? p??t? d?s? ???e? aµ?s?? µet? t? ?????s?,
  t?te ????????ta? t?sse??? d?se?? t?? eµß?????.
• ? t?ta?t? d?s? µe µes?d??st?µa t??????st?? 4
  eßd?µ?d?? ap? t?? t??t?, ??? ????te?a ap? t??? 6
  µ??e? t?? ????.
• S?????S???? ??????? ?? ????G?????? ???? ???
  ?????? ?O? 6 ???????O? ??S ?O?S.

25
??????? ?ep?-??????S ??????OS??S

• ?a?d?? lt 10 et?? p??pe? ?a eµß???????ta? µe t?
  µ?s? d?s? t?? e?????a.
• ?t?µa µe a??s??atast???, p??pe? ?a eµß???????ta?
  µe t? d?p??s?a d?s?.
• S a?t?? t?? pe??pt?s?, ? eµß???asµ?? ???eta? µe
  t?sse??? s??????? d?se??.

26
??????? ?ib

• ???f?lt6 µ???? ?????e?ta? st?? 2?, 4?,6? ?a?
  12?-15? µ??a.
• ???f? 7-12 µ???? d?? d?se?? ?a? µ?a
  a?aµ??st???15 µ????.
• ?a?d?? 15 µ????-5 et?? µ?a d?s?.
• ?a?d?? gt 5 et?? de s???stata?.

27
EMBO?IO D?aP

• ???????eta? ??a pa?d?? ?????a?lt 7 et??.
• ?????d????aµµa 2??, 4??, 6?? µ??a?.
• 4? d?s? 1 ????? µet? t?? t??t? d?s?.
• ?pa?a??pt??? d?s? 4??-6?? ?????? t?? ????.
• Se ?????a 11-12 et?? Td.(epa?????? a?? de?aet?a
  d?a ß???, ??? t?? ?????a t?? 65 et??.)

28
BCG

• G??eta? st?? ?? ??µ?t????, af?? p??????e?
  Mantoux.
• ???s??? st?? ?µ?de? ?????? ???d????.
• Mantoux p??pe? ?a ???eta? se ?????a 1, 4-6 et??
  ?a? sta a?eµß???asta pa?d?? st?? ?????a 11-12
  et??.

29
?????? ??? ??????? S? ?????S ?????? ???????? G??
F?????OS?

• ?eta??ste? ap? ???e? µe ????? ? µ?s? de??t?
  e?d?µ???t?ta?.
• ?ata???sµ?? a????a???.
• ?a?d?? µe Mantoux (-) st?? ???????e?a t?? ?p????
  ?p???e? ?t?µ? µe ?et??? pt?e?a.
• ?e???? µ?t???? p?? ????? µ?????e? ap? t?? HIV(???
  ß??f? s?µpt?µat??? ??a AIDS).
• ?e???? st? pe??ß????? t?? ?p???? ?p???e? ?t?µ? µe
  TB.(eµß???asµ?? ?at? t? ?????s?).

30

?e?µ?a?t?d?as? Mantoux
?????s? gt5 mm ?paf? µe p?s???ta ?a???????? e???µata st?? a/a ???a??? ??????? s?µe?a t?? ??s?? ???s??atast???
?????s? gt10 mm ?a?d?? lt 4 et?? ?p??e?µe?? ?????? ??s?µa ?a?d?? µe a???µ??? p??a??t?ta ???es?? Ge????e? se ???e? µe a???µ??? ep?pt?s? ?paf? µe ?p?pte? ?????????? ?µ?de? ?a??d?a se ???e? µe a???µ??? ep?pt?s?
?????s? gt15 mm ()

RED BOOK 2006
? Mantoux ?et???p??e?ta? 2-12 ßd?µ?de? µet? t??
µ????s?
31
??µ??e?a t?? f?µat???a?t?d?as?? se ?t?µa
eµß???as???ta µe BCG

• ?p?????? d?s????e? st?? e?µ??e?a
• ?p?? t?? ??s??
• ?st????? epaf?? µe p?s???ta
• ?eta??ste?s? ap? ???a µe ????? s????t?ta t?? ??
• ?e???? d??st?µa ap? t?? eµß???asµ? (gt5 ?t?)
• ?????s? gt 15 mm

RED BOOK 2006
32
??????? MMR

• ??????s? p??t?? d?s?? se ?????a 12-15 µ???? ?a?
  de?te??? d?s?? se ?????a 4-6 et??.
• ?p??e? ?a µe??se? t? d?a???st??? a??a t??
  Mantoux.
• ?a pa?eµß???eta? t??µ??? e?? ??e? p??????e?
  ??????s? sfa?????? ? µet????s? a?µat??.
• ???et?? ?a? e?????µa e??a? s?et??? s?????
  a?ep???µ?te? e????e?e?, p?? eµfa?????ta? 7-12
  ?µ??e? µet? t?? eµß???asµ?.

33
S????G???? ??????? ???? ??? ???????????????

• ??? ? ??a??? t?? eµß???asµ?? ???e?lt7 µ????, t?te
  ????????ta? 4 d?se?? t?? eµß?????( ? t?ta?t? d?s?
  µ???? t?? ?????a t?? 15 µ????).
• ??? ? ??a??? ???e? µeta?? 12??-23?? µ??a, t?te
  d?? d?se?? µe µes?d??st?µa 6-8 eßd?µ?de?.
• ??? ? ??a??? ???e? µet? t?? 24? µ??a, t?te sta
  ???? pa?d?? ???eta? µ?a µ??? d?s?.

34
????? S? ??????? G?? S?????S ????????????????S
????O???S

• ???? ß??f?, µ???? pa?d?? ?a? e?????e? gt60 et??
• ?t?µa p?? ????? µ?????e? ap? HIV.
• ?t?µa µe ?ef??s??? s??d??µ? ? ?????a ?ef????
  a?ep???e?a.

35
????? S? ???????? ??????? G?? ????????????????S
????O???S

• ??µ?sfa?????p??e?e?
• S???e??? ? ep??t?t? asp????a
• ???s?a?ep???e?a (s???e???, ep??t?t?,
  a??s??atast???)
• ?????? ??s?µa (?????f??????, a?ap?e?st????, S.?.)
• ??a???? ?.?.?.
• ?µß???asµ?? e???????gt60 et??

36

• ?a ?t?µa µe a???µ??? ???d??? p?e?µ????????????
  ???µ??e?? p??pe? ?a eµß???????ta? ?a? µe t?
  23-d??aµ? p???sa??a??d??? p?e?µ??????????? eµß????

37
????sa??a???? eµß???? p?e?µ??????????

• 23-d??aµ?
• ?e? e??a? a?t??????? se ?????e? lt2 et??
• ????? d????e?a a??s?a?
• ?µß???asµ? ?µ?d?? ?????? ???d????

38
S????G???? ??????? ???? ??? ????GG???????????

• Se ß??f? lt12 µ????, ????????ta? 2 d?se?? 2, 4
  µ???? µa?? µe ta ???a eµß???a ?a? epa?a??pt???
  d?s? st??? 18 µ??e?.
• Se pa?d?? ??? t?? 12 µ????, µ??? µ?a d?s? t??
  eµß?????.

39
?p?? p???sa??a??d??? µ??????t?d???????? eµß???a

• ?? d?d??aµ? A, C
• ?? tet?ad??aµ? A, C, Y, W135
• ?a?? a?t???????t?ta se ?????e? lt 2 et??
• ???s?a µ????? d????e?a? (3 ?t?)
• ?µß???asµ? e?d???? ?µ?d??
• a??s???????? d?ata?a???, asp????a, ta??d??te?
  se e?d?µ???? pe??????, p??s?p??? e??ast?????,
  ??e??? ep?d?µ???

40
????????????? S???????O? ??????O?

• ???a? a??s??????? ?a? ??a ta ß??f?.
• ????a???? a??s?a?? ap??t?s? ??µ???? ?a?
  ??tta????? t?p??.
• ??s????? a??s?a a?????(s???????? a??s?a),
  e?att????ta? t? ????fa??????? f??e?a.

41
??????? ???? ??S ????????G??S

• ?p???sa ?t?µagt12 et?? d?? d?se?? µe µes?d??st?µa
  4-8 eßd?µ?d??.
• ?a???e? ??a??p???t??? a??s?a.
• ???a??t?ta ??s?s?? se eµß???as???ta pa?d?? µ????
  15 (?p??te?? p??e?a ??s??).
• ?????e?ta? se ?t?µa ?????a?gt12 µ???? se µ?a
  d?s?.
• ???a??t?ta a???s?? t?? eµf???s?? ??p?ta ??st??a
  st??? e?????e?()
• ?a???e? p??stas?a, a??µ? ?a? e?? ???????e? µ?sa
  se t?e?? ?µ??e? ap? epaf? µe p?s???ta.

42
??????? ?????????S ?

• ?????e?ta? se ?????a ??? t?? 2 et??, se d??
  d?se??, µe e????st? µes?d??st?µa 6 µ????, se
  pa?d?? p?? a?????? se ?µ?de? ?????? ???d????.

43
????????S ???????S??? ???? ??S ?????????S ? S?
?O??S ?? ?????? ??? ??S? ????????????

• ?a??d??te?
• ?pa??e?µat?e? ??e?a?
• ?pa??e?µat?e? d?a????s?? t??f?µ??
• ???s?p??? ?d??µ?t??
• ??e?st?? p????sµ??
• ?µ?f???f???? t?????µa?e??
• ?t?µa µe ?????a ???µ??? µe t?? ?? t?? HB

44
????????S ???????S??? ???? ??S G?????S

• ?s?µa ? ???e? ?????e? p?e?µ???p??e?e?.
• ?a?d?a?? ??s?? µe s?ßa?? a?µ?d??aµ??? d?ata?a??
• ???s??atast???
• ??µ?sfa?????p??e?e?
• ?a?d?? p?? ?aµß????? ??????? asp?????
• S.?. ? ???? µetaß????? ??s?µa
• ?????a ?ef??p??e?a
• ??e?st?? p????sµ??
• ?pa??e?µat?e? ??e?a?
• ?pa??e?µat?e? p?? as??????ta? µe p???e????
• ?t?µa ?????a? 60 et?? ?a? ???

45
?µß???? ?at? t?? ??ta???

• ?µß???? ap? ???te? e?as?e??µ????? ????,
  ???????µe?? per os.
• S??µa 2??, 4??, 6?? µ??a? (5-d??aµ?).
• 2?? ,4?? µ??a? (µ???d??aµ?)
• ?????e?ta? µ?sa st?? p??t? ????? t?? ????.
• ???s??? se ?atast?se?? a??s??atast????!!!

46
E?????S ??????OS??S

• ?????a ?e????
• ???s??atesta?µ????
• ???s?
• ?s?e?e?? µe AIDS
• ??????s? sfa?????? ?a? pa?a????? a?µat??

47
???????S??? ???O?O?

• ? eµß???asµ?? ???eta? ?a??????, ß?se? t??
  ?????????a? ?????s??.
• ?a p????a eµfa?????? ??a??p???t??? a?t?s?µat???
  ap??t?s?.
• ?a?e????e?e? de? pa?at?????ta? se µe?a??te??
  ßa?µ? ? ??tas?.

48
Ge????? a???? eµß???asµ?? se a??s??atesta?µ??a
?t?µa

• ?p????d??a e??a? ta ???ta eµß???a
• ?a ad?a??p???µ??a ?e??? eµß???a ?????ta? s?µf??a
  µe t? p????aµµa eµß???asµ??
• ? a?t?s?µat??? ap??t?s? µp??e? ?a e??a?
  e?att?µ???
• ????????ta? 3 µ??e? µet? t?? d?a??p? ?e?ape?a? µe
  ?-sfa?????
• ?e? ?????e?ta? OPV st??? s???e?e?? e?? t? MMR ?a?
  t? eµß???? t?? a?eµe??????? ???eta? ?a??????
• ?a a??s??atesta?µ??a ?a ap?fe????? epaf? µe
  eµß???as???te? µe OPV ??a t??????st?? 4-6
  ßd?µ?de? µet? t?? eµß???asµ?
• S???stata? ? ta?t???? eµß???asµ?? t?? µe??? t??
  ???????e?a?

49
?????? ?? AIDS

• ??? ???te? µ???????a??sµ?? (e?. MMR).
• To MMR ?????e?ta? se pa?d?? ?et??? ??a HIV, ?????
  s?ßa?? a??s??atast???.
• DTaP ?p?? st? s??µa.
• HBV
• ?ib
• IPV (OPV apa???e?eta?).
• G??pp?? (???e ????? µet? t??? 6 µ??e?).
• ??e?µ??????????
• M??????t?d???????

50
??????s? sfa?????? ?a? pa?a????? a?µat??

• ? pe?????sµ?? af??? ?????? t? eµß???? MMR
• 3 µ??e? µet? ??????s? ?-sfa?????? ??a t?ta??,
  ?pat?t?da ?, ?pat?t?da ?, ??ssa
• 6 µ??e? µet? ??????s? ?-sfa?????? ??a ??a??,
  a?eµe??????, S?, ????? a?µa ?a? p??sµa
• ?p??at?stas? ? ?e?ape?a a??s?a?ep???e???, ITP, ?.
  Kawasaki
• (a?????a µe t? d?s? )
• 8 µ??e? ??a d?s? 300-400 IgG mg IgG /kg
• 11 µ??e? ??a d?s? gt1000 mg IgG /kg

51
???????????S ???????S?O?

• ???a eµp??eta ??s?µata.
• S?ßa?? a??e????? a?t?d?as? se p??????µe?? d?s?
  eµß?????.

52
?? µ????? sta eµß???a

• ?a?as?e?? eµß????? ap? d?a????d?a?? f?t?
  (trangenic plants)
• ?µß???a µe d?ade?µ??? ??????s? t?? a?t?????? se
  s??d?asµ? µe t?? ?at?????? a??s?e??s??t??? ??s?a
• ?µß???a µe t? µ??f? ??????? ?e?asµ?? ? sta?????
  (???pp?)
• ?µß???a ??a µ? ???µ?d? ??s?µata (S?, ??s??
  Alzheimer)