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The Effects of Reduction Potential and Number of
Disulfide Bonds on the Correct Folding of
Lin-12/Notch Repeats (LNRs) Using Human Notch 1
LNRA as a Model System Lauren Choi, Wellesley
College Advisor Dr. Didem Vardar-Ulu
Results
Ca2 Addition Does Not Significantly Change
Thermodynamics of Mutant LNRA_CG Folding
Introduction Notch receptors are
multi-domain trans-membrane proteins that are
important for cell-cell communication and
development.