Neoplasia DR OSSAMA I NASSIF FRCPC

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Dr. Osama I Nassif. MD, FRCPC.Associate
professor consultant pathologist.Pathology
Dept. King Abdullaziz University.
NEOPLASIA
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NEOPLASIA

• What
• Why
• Where
• When
• How

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Definition

• An abnormal mass the growth of which exceeds and
  is uncoordinated with that of the normal tissue
  and persists in the same excessive manner after
  the cessation of stimuli which evoked the change
  .
  

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DIFINITIONS

• TUMOR VS NEOPLASM
• ONCOLOGY ONCOS LOGOS
• BENIGN RELATIVELY INNOCENT
• MALIGNANT CANCER ( CRAB )

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Nomenclature
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Benign tumors oma cell type

• Papilloma benign surface neoplasm

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Benign tumors

• A Polyp mass projecting above a mucosal surface

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Benign tumors

• An Adenoma benign epithelial neoplasm producing
  or arising from glands

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Benign tumors connective tissue

• Leiomyoma A benign neoplasm of smooth muscle
  

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NEOPLASIA LEIOMYOMA HPF
DR OSAMA I NASSIF FRCPC

• Leiomyoma

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Nomenclature
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Benign tumors

• Fibroadenoma
• more than one cell type ,
• from one germ layer

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Benign tumors

• Mixed tumor of salivary glands (pleomorphic
  adenoma) Derived from one germ layer

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Nomenclature
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Benign neoplasms

• Mature teratoma more than one neoplastic cell
  type derived from more than one germ layer.

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Malignant tumors
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Benign Vs malignant
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Malignant neoplasmsdifferentiation and anaplasia

• Adenocarcinoma

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Malignant neoplasms
Differentiation and anaplasia

• Squamous cell carcinoma
• Well-differentiated .

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Benign vs Malignant
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Anaplasia

• Pleomorphism
• Hyperchromasia
• High N/C ratio
• Polynuclearity
• High mitotic rate
• Bizarre shapes/sizes
• Atypical mitoses

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HAVE A NICE DAY