HUMAN CARCINOGENESIS :BREAST CANCER MODEL

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DRUG ABUSE ADDICTION Alcohols, amphetamines
canabinoids
?????????????? ??. ????? ????????????? Noppamars
Wongwitdecha, Ph.D. Associate Professor Center of
Neuro-Psychopharmacology School of Medicine
School of Pharmacy Walailak University
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OBJECTIVES

1. Describe the principles of drug abuse and
   addiction
2. Explain the reward pathway with diagram
3. Describe mechanism of tolerance, dependence and
   withdrawal
4. Describe the neurobiology of abused drug
5. Discuss the pharmacological actions, mechanism
   and site of action of alcohols, amphetamines and
   canabinoids
6. Describe the major signs and symptoms of
   intoxication, overdose and withdrawal of drugs 5
7. Explain the principles of the treatment of
   overdose of drugs 5

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Introduction
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Definition drug abuse addiction
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Definition Tolerance, psychlogical
physiological dependence
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Definition Withdrawal, intoxication
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Mechanism of tolerance
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Mechanism of dependence
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Reward pathway (with diagram)
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Principles of drug abuse and addiction
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Alcohols, Amphetamines, Canabinoids
1. Chemical structures properties2.
Pharmacological actions - mechanism site
of action3. Major signs and symptoms of -
intoxication, - overdose, -
withdrawal4. Principles of treatment of -
overdose - withdrawal
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References
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