HUMAN CARCINOGENESIS :BREAST CANCER MODEL

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NEUROTRANSMITTERS AUTACOIDS
??.??. ????? ????????????? Noppamars
Wongwitdecha, Ph.D. Associate Professor Center of
Neuro-Psychopharmacology School of Medicine,
Walailak University
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Objectives

1. Define neurotransmitters, neuromodulators, and
   autacoids
2. List the major neurotransmitters and autacoids
3. Describe the sources, localization,
   distribution, synthesis, storage, release and
   removal of 2
4. Discuss the physiological functions and
   pharmacological actions of 2
5. Classify the receptor subtypes of 2
6. Write down the agonists and antagonists of 5
7. Discuss the pharmacological actions, clinical
   uses and major adverse effects of 6

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Outlines

1. Definition of neurotransmitters, neuromodulators,
   and autacoids
2. Major neurotransmitters and autacoids
3. Sources, localization, distribution, synthesis,
   storage release and removal of 2
4. Physiological functions and pharmacological
   actions of 2
5. Classification of the receptor subtypes of 2
6. Agonists and antagonists of 5
7. Pharmacological actions, clinical uses and major
   adverse effects of 6

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Neurotransmitters Autacoids

1. Dopamine
2. Histamine
3. GABA
4. Glycine
5. Kinins Bradykinin, kallidin
6. Eicosanoids
7. Prostaglandins
8. Substance P
9. CCK

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Introduction
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History
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Chemical Structure
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Chemical Properties
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Source
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Synthesis, Storage, Release, Removal
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Localization Distribution

• Pathways in the CNS

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Pathways in the PNS
Localization Distribution
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Physiological activities
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Pharmacological Actions
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Tissue organ system effects
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Receptors
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Receptor subtypes

• Classification
• Localization Distribution
• - CNS
• - PNS
• Physiological Functions
• Agonists Antagonists

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Agonists

• Chemical propertyPharmacological
  actionsClinical usesAdverse effects

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Antagonists

• Chemical propertyPharmacological
  actionsClinical usesAdverse effects

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References
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