Gene expression changes between uncomplicated and complicated groups

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Gene expression changes between uncomplicated and
complicated groups
Grouping Criteria 0 1 4 7 14
uncomplicated (n55) MAX_MOF lt 6, ToR lt5 55 51 42 33 13
             
complicated (n64) MAX_MOF gt 6, ToR gt5 64 63 62 57 45
complicated (n41) MAX_MOF gt 6, ToR gt14 41 40 39 37 30
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Gene Expression between uncomplicated and
complicated groups (1)
Grouping Criteria 0 1 4 7 14
uncomplicated (n55) MAX_MOF lt 6, ToR lt5 55 51 42 33 13
             
complicated (n41) MAX_MOF gt 6, ToR gt14 41 40 39 37 30
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Significant Genes

• 10 of the genes (5285/54676) significantly
  changed between the two groups over the first 14
  days post injury at FDR lt0.001.
• Among these genes, 1746 changed more than 1.5
  fold, of which 205 changed more than 2 fold.

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Adding more control columns
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Cluster 1 and 2 - UP
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Cluster 6 and 7 - Down
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Cluster 3,4,5
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HLAs among significant genes
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Adding more control columns
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1746 genes with gt1.5 fold change
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1746 genes with gt2fold change
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Genes with gt2fold changes
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Up
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Down
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Conclusions (Preliminary)

• Comparing the temporal pattern of genomic
  response in the first two weeks post trauma
  between 55 patients with uncomplicated recovery
  (group 1MOFlt6, ToRlt5) and 41 patients with
  complications (MOFgt6, ToRgt14 days) show
  significant differences in 10 genes in WBCs
• Several immune response pathways (including
  B-cell signaling) are seen further (or prolonged)
  upregulated, while antigen presentation, many T
  cell related pathways, and protein synthesis and
  post-transcriptional modifications are further
  downregulated in complicated trajectories after
  injury.

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