???????? ?????? ???????? D - PowerPoint PPT Presentation

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???????? ?????? ???????? D

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, . - , 11-15 2006 . – PowerPoint PPT presentation

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Title: ???????? ?????? ???????? D


1
???????????? ????????????? ???????? ? ??
?????????? ?????? ? ???????????? ??????????
????????????? ????? ?? ??????????????, ???????? ?
?????????? ?.????-???, 11-15 ?????? 2006 ?.
  • ??????? ?.?., ??????????? ?.?., ??????????? ?.?.,
    ??????? ?.?.
  • ???? ???? ????????????? ????????????????
  • ??????, ??????

2
????? ???????? ?
????????? Picornaviridae ??? - Hepavirus ?????
ssRNA, 7500 bp ???????? ????????
????????-???????? ??????? ??????? ?
??????? ??????? ?????? ???????
3
?????????????????? HAV-????????
4
???????? ?????? ???????? ?
100
95
91
83
85
83
98
87
82
NJ, K80
5
?????????????????? ????????? HAV
IIIA
IA
IA
IA
IIIA
IIIA
II
IB
IA
6
????? ??????????????? HAV ?? ??????
?????????????????? ???
??????? 3?, 3?
7
???????? HAV ? ??????
???????
N15
???????????
????????
N22
N105
8
?????????????? ?????????? ?????? HAV
9
  • ????? HAV ???????? ??????? ????????????
    ?????????????
  • ???????, ????????????? ? ?????? ? ? ????? ???????
    ???????? ?, ?????????

10
????????????? ???????
  • ??????? ???????? ? ???????? ???????,
  • ??? ???? 2005
  • 662 ?????????????????? ??????

11
????
70 ??
???????
30 ??
??????
12
20 ??? 15 ???? 2005 ?.
???????? ?????
?????????? ?????
?????????? ?????
13
??????? ???????? ? ???????? ???????
14
????????????? ???????
  • ??????? ???????? ? ?. ?????? ????????, ????????
    ??????? 2005
  • 2912 ?????????????????? ???????

15
???????? ??????? ??????????????
????????????? ?????????? ?? 22.09.05
5.09
?. ?????
13.09
18.09
16.09
?. ???
16
?????????
????? ?????????? ?????????????
?????????????? ???
?. ?????
?. ???
17
?????????
????????????? ??????? HAV
?????????????? ???
?. ?????
?. ???
18
?????????? ?? ?????????????? ????????
???????????? ????????????? ??????????????
19
????????? ??????????????? HAV ??????? I
VP1/2A 300 ??.
???
IB
???????, ??????, ?????
73
IA
Minimum Evolution, F81 (pApCpGpT1)
90
20
????????? ??????????????? HAV ??????? III
VP1/2A 300 ??.
??????, ???????, ????????,???????????
????????
???????
??????????????
????????
Minimum Evolution, F81 (pApCpGpT1)
21
Minimum Evolution, F81 (pApCpGpT1)
VP1/2A 400 ??.
54 ????????????? ??????? ?? ??????????
??????????? ????? ??
IA
???????, ???????
???????? ?????? ?? ?????????????????? ???????
22
???????? HAV
??????? ????? ???, ?????????????
?????????, ?????? 1999 ?.
?????? ?????????? ?? ????? ???????
23
??????
  • ????????? ????????????? ??????? ?????????
    ???????? ????????????? ???????, ???????? ????????
    ??????
  • ????????? ?????? HAV ? ?????????? ????????
    ??????? ?? ??????????????? ??????? ???????
    (??????????) ? ??????????? ????????????
    ????????????
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