Pharmacokinetics

1
Carcinogenicity and
General Toxicology
Reproductive and Developmental Toxicology
High
Safety Pharmacology
High
Medium
Low
0
2
4
6
8
10
12
14
Priority ( responses per priority level)
Pharmacokinetics
High
Medium
Low
Metabolism
Distribution
Absorption
Analytical Method/Valid. Report
Medium
0
2
4
6
8
10
12
14
Priority ( responses per priority level)
Genetic Toxicology
High
Medium
Genotoxicity (in vivo)
Low
Genotoxicity (in vitro)
Bacterial Reverse Mutation Assay (Ames)
Mammalian Cell Micronucleus Test
In Vivo Comet Assay
Mammalian Chromosome Aber. Test
Mamm. Erythrocyte Micronucleus Test
E. coli Reverse Mutation Assay
Mamm. Bone Marrow Chrom. Aber. Test
Mammalian Cell Gene Mutation Test
Sister Chrom. Exchange Assay in Mamm.
Tg. Rodent Som. Germ Cell Gen Mut
Liver Unsched. DNA Synthesis
0
2
4
6
8
10
12
14
Priority ( responses per priority level)
Pharmacology
High
Medium
Low
Pharmacology Studies
Primary Pharmacodynamics
Low
0
2
4
6
8
10
12
14
Priority ( responses per priority level)
Figure 2A. Priorities for Nonclinical Study
Types. Individual study types were rated as high,
medium, or low priority by survey respondents.
Red Font indicates study groups that have been
standardized. Blue font denotes study types that
are currently being standardized. Asterisk ()
indicates that all study types within the
Reproductive and Developmental Toxicology were
of a similar high priority based on survey
results.