Amnesia

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Amnesia HM - 1953 (27 y/o) Bilateral medial
temporal lobe damage
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Assessment of Memory Digit span 1 - HM poor
(8 - tops) Block tapping - HM poor ( 5
taps) Mirror Drawing - motor learning HM
fine Rotary Pursuit - motor learning Incomplet
e pictures Operant conditioning
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Why two types? Flexibility
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Memento
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Amnesia Dementia Korsakoffs Syndrome -
chronic alcoholism - thiamine (B1) - medial
diencephalon damage Alzheimers Disease -
diffuse damage - Ach in medial
forebrain? Concussion Posttraumatic memory
loss - retrograde anterograde - temporary -
electroconvulsive shock therapy - similar -
interfere with consolidation
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Hebb Rule if a synapse is repeatedly active at
the same time that the post synaptic neuron
fires, the synapse will be strengethened. Hebb
Synapse a synapse that increases in
effectiveness because of simultaneous activity in
the presynaptic and postsynaptic neurons. NMDA
receptor - Glutamate
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Inferior temporal (perirhinal) lesions disrupt
this
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Hippocampus lesions disrupt this
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Delayed Non-matching-to-sample - frontal lobe
lesions disrupt
Frontal lobe important for remembering the task
demands
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space
object
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The general arrangement of the pool.
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In a place-learning task, a rat is put into the
pool at various starting locations. The animal
must learn the location of a hidden platform,
which can be done only by considering the
configuration of visual cues in the room-windows,
wall decoration, potted plants, and the like.
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In a matching-to-place task, the rat is again put
in the pool at random locations, but in this case
the hidden platforms is in a new location each
test day. The animal must learn that the
location where it finds the platform on the first
trial of each day is the location of the platform
for all that days trials.
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In a landmark-learning task, the rat is required
to ignore the room cues and to learn that the cue
on the wall of the pool signals the location of
the platform.
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