Introduction to meta-analysis in Review Manager (RevMan).

1
Introduction to meta-analysis in Review Manager
(RevMan).

• Ewelina Rogozinska
• CT Data Assistant/Researcher
• Women's Health Research Unit

2
The systematic review process
Search bibliographic databases
Formulate research question
Design search strategy
Further selection of primary studies using
inclusion criteria
Identify possible papers from titles/abstracts
Retrieve papers
Quality appraisal
Synthesis
Extract data

• Formulate research /
• policy conclusions

3
Session overview

• Brief introduction
• What do we use RevMan for?
• Setting up RevMan file
• Practical part
• Adding studies
• Add outcome
• Data entry
• Conducting meta-analysis
• Add new comparison
• Introducing subgroups
• Generating plots and graphs

4
Working with RevMan

• Review Manager (RevMan) - software used for
  preparing and maintaining Cochrane Reviews.
• You can use RevMan for protocols and full
  reviews.
• It is most useful when you have formulated the
  question for the review and allows you to
• prepare the text,
• build the tables showing the characteristics of
  studies and the comparisons in the review,
• add study data,
• perform meta-analyses and
• present the results graphically.
• It can be downloaded from Cochrane web page
  http//ims.cochrane.org/revman

5
Tasks

• Add two new studies Mardones 2007 and Zhou 2012
• Add new outcome Birth weight (g) under
  comparison Fish oils and specify
• Type of data continuous
• Analysis model random
• Effect measure mean difference
• Analysis details totals and subtotals
• Graph details
• To outcome Birth weight (g) add studies
  Mardones 2007 and Zhou 2012
• Transfer earlier extracted data for birth weight
  from these two studies

Introduction to meta-analysis in RevMan Ewelina
Rogozinska
6
Tasks

• Create new comparison Diet and fish oils and
  specify
• Type of data dichotomous
• Stat method Mantel-Haenszel
• Analysis model random
• Effect measure Risk Ratio
• Analysis details totals and subtotals
• Graph details scale 10.0
• Add studies and create two subgroups
• First diet
• Second fish oils
• For outcome Pre-eclampsia (PET) generate
• Forest plot
• Funnel plot
• Risk of bias graph

Introduction to meta-analysis in RevMan Ewelina
Rogozinska
7
(No Transcript)