Genetics of Osteoporosis

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Genetics of Osteoporosis
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Genetics of Osteoporosis
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Genetics of Osteoporosis Clinical Aspects

• Data sources
• Dubbo
• Twins
• Australian Consortium (POWH, Gosford, Melborune,
  Perth)
• St Vincents ODP BMD
• Data Management
• Integrity and accuracy
• Availability (ethics, authorisation)
• Utility (centralisation)
• Retention, storage, and retrieval (pedigrees)

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Genetics of Osteoporosis Progress

• Strategy Parents differing by gt2SD FNBMD
• Dubbo 26 families according to 10-30
  percentiles
• Other Australian centres
• Twins 400 DZ pairs of both sexes
• Clinical Genetic interaction within the Garvan