???????????? ??????????? ????????????? Sr-82 ? Tl-201 ?? ????? ????????? ?????????? ????. ????-??????.

1
???????????? ??????????? ????????????? ??
?????????? ???????? ?-80.
2
????? ????????? ??? ????????? ????????????? ???
????????. 1 - ?????????? 2 - ??????? ?????????
3 ?/? ???? 4 ??????? ?????? 5
????-?????????
3

• ????????? ???? ????????????? ???????.
• 1-? ????????????? Sr82 (?? 1 ????), ??????????
  ??????? ?????????, ??????? ? ???????, ???? 2-3
  ????
• ??????????,
• ???????? ?????? (3 ?????),
• ??????? ?????????, ???????????, ?/? ???? ????.
  ????.
• ?????? RbCl
• ?????????? ?????????? Sr82 - Rb82.
• .
• 2-? ???? 4-5 ???
• ??? 2 ??????? ????????? ,
• ??????? ??????,
• ???????? ???????????????,
• ????-????????? off-line.
• 3-? ???? 6-8 ???
• ????????? ?????? ???????????????.
• ???????????? ?????????,
• ??????????????? ?????? ?????????.

4
DIAGNOSTIC RADIOISOTOPES S67Zn(p,n)67Ga
68Zn(p,2n)67Ga natKr(p,xn)81Rb5. 82Kr(p,2n)81Rb
111Cd(p,n)111In 112Cd(p,2n)111In5 123Te(p,n)123I
124Te(p,2n)123I 124Te(p,n)124I
127I(p,5n)123Xe?123I 127I(p,3n)125Xe?125I
124Xe(p,2n)123Cs?123Xe?123I 124Xe(p,pn)123Xe?123I
203Tl(p,3n)201Pb?201Tl 203Tl(p,2n)202mPb?202Tl 2
03Tl(p,4n)200Pb?200Tl
5
POSITRON EMITTERS for PET 69Ga(p,2n)68Ge. natGa(p,
xn)68Ge 85Rb(p,4n)82Sr natRb(p,xn)82Sr
6
Los Alamos
LARGE-SCALE ISOTOPE PRODUCTION WITH AN INTENSE
100 MEV The RbCl targets and gallium targets are
disc shaped and have a nominal diameter of 50 mm.
Up to three targets are irradiated
simultaneously with nominal incident energies of
90 MeV, 65 MeV and 30 MeV. Targets are
separated by spacers to form 5 mm thick cooling
channels between the target faces. Typical
cooling water velocities flowing over the target
faces range between 2 and 5 m/s.
7
Los Alamos
8
Los Alamos

????????? ?????????????????? ??????? ?? Rb ?
RbCl, ???-??????
?????? ????? ? ??????? ???????? ??? ???, µ? ????? ?????????, ????? ?????????? Sr82 ?? ?????? ??????, ??
Rb ???. 50 94-101 130 2 1,5
RbCl 10 65-40 80 2 0.5-0,7
9
Los Alamos
10
Los Alamos
11
Los Alamos
????????? ????????? ??????? ???????? 98
??????? RbCl, ?? ??? 54 ? ???????? ?? ????. ?????
(????????????? ?????????? ????? ?? 100 ??
200µ?) 44 ?? ?????? ???????? 625 (??? ?????
??200 ?? 220µ?). 38 ??????? ? ???. Ga ( ???
????? ?? 100µA ??250 µA
12
Los Alamos
13
Los Alamos
Rb-82 Dosage Rubidium chloride injection obtained
from Cardiogen-82 (Rubidium Rb-82 Generator) is
intended only for intravenous administration
utilizing an appropriate infusion system that is
labeled for use with the generator. The usual
adult (70 kg) dose(single injection) is 1480 MBq
(40 mCi) with a range of 1110-2220 MBq (30-60
mCi). The dose must be administered at a rate of
50 mL/minute not to exceed a cumulative volume of
200 mL. A single dose of 2220 MBq (60 mCi) should
not be exceeded. No more than 4440 MBq (120 mCi)
should be administered in a multiple injection
series.
????????? ??????? ?????????? ???????? ?????????
? ???????? ?????????? ????????? ???????? ???
?????????????? ? ?????????? ??????
???????????? ??????????? ???????????? ???????
??????????? ????. ???????????? ???????????
??????? ??? ????????????
14
??????
15
??????
???????????? ????? Sr-82 ??? ?????? ?????????? ?
?????? ?????????? ????? a,c,d,f,e ??????, b
???????????.
16
KIRAMAS (?????)

• Radiopharmaceuticals Laboratory, Korea Institute
  of Radiological and Medical Sciences (KIRAMS)
• The radiochemical purities higher than 99.7 .
• Accelerator 40MeV, 220 µA
• A water-cooled carbon collimator
• 4 external beam lines.
• wobbler magnet to rotate the beam.
• Pneumatic transport.

Radionuclides C-11 F-18 1-123 Tl-201
Yields mCi/µAh 90 10 3 3
17
?????? ??????? ????????? ????
18
??? ??? ???????????????.
19
??? ?????????? ? ???????? ???????.
20
Sr Rb ????????? 1 ??????? ???????? ?? ???????
2 ?????? ????? ?? SrCO3
21
?????? - ???????????? ??????????? ??????????,
?????????? ??? ?????????????? ????? ???????? ?
?????????????? (?? ???? ???????? ?????????
???????? ???????) ?????????
???????? Ni c ?????????????????
22
? ?????????? Sr-Rb ???????????? ??????????????
?????? ?? ?????? ??????? ?????????? ????????? -
Sn, Ti, Zr, Ta ? ??., ? ????? ???????????????
?????
23

• ????????????? ?????????? ???????????? ?????????
  ???????????? ?????????????
• K d ( A i -A f )/ A f v/m (2)
• ???
• ? Ai ????????? ?????????? ? ????????
• A f - ???????? ??????????
• v - ????? ?-?? (??)
• m - ????? ????????(?)

24
??????? ?? ????????
25
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26
Sr Sr Rb Rb Kr Kr
A ?1/2 ?1/2 ??? ??????? ?1/2 ??? ??????? ?1/2 ??? ???????
80 1,8? 1,8? e 30? ß ????.
81 22???. 22???. ß 30,3???. 4,6? ?? e, ß 13,? 2,3105?. ??, e
82 25,3??. 25,3??. e 6,3? 1,23???. ?? e, ß ????.
83 5? 32? 5? 32? ?? e, ß 86,2??. e 1.83? ????. ??
84 ????. ????. 20,5???. 32,8??. ?? e, ß ????.
85 67,7???. 64,9??. 67,7???. 64,9??. ?? ß - ????.(72) 4,8? 10,75?. ?? ß -
86 ????. ????. 1???. 18,7??. ?? e ß -, ??? ? ????.
87 2,8? ???? 2,8? ???? e, ??? ? ????.(30) 76???. ß -
27
(No Transcript)
28
(No Transcript)
29
(No Transcript)
30
????????????? ??????????? ?????? ??????????????
?? ?????????? ???????
31
????????????? ??????????? ?????????
????????????? ??? ?????????? ??????????
?????????? ??????? ? Am-241 (). ????????????
????? ????????? 1019?, ????????? ???????????
???? 108 ??.
32
. ???????? ????????????? ?????????????
???????????????? ????? ?? ??????, ??????????
Am-241, Eu(Eu-152) I(I-125), ??? ?????????
??????????? a-????????????? ?? ??????? ?
????????? ?? ? ????? ????????? ??????????, b- ??
?? ?? ???????? ??????? ? ???????? ?????? ???????
????????????, c- ?? ??????? ??????? ? ?????.