1 mV

1
1 mV
2
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Barbiturates Benzodiazepines Alcohol General
Anesthetics
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Chem. driving force
Elec. driving force
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Kainate Receptor
AMPA Receptor
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Glutamate receptor excitatory postsynaptic
currents (EPSCs)
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Hippocampal long-term potentiation
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metabotropic receptors
ionotropic receptors
Effector
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Ionotropic receptor synaptic actions
Metabotropic receptor synaptic actions
Indirect
Direct
slower (0.1-100 s)
fast (ms)
open or close channels
open synaptic channels
resting channels, voltage-gated
channels, fast synaptic channels
channels only at synapse
modulate excitability
excite or inhibit AP
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ACh
closure
PIP2
PLC
Gq
DAG
IP3
Protein kinase C
Ca release
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1.5
2. Decrease in slow delayed rectifier K current
nA
1. Decrease in resting outward K current
0
1. Slow EPSP