Scientific Reports

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Scientific Reports
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JBC
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JBC
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JBC
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Editorials Breast cancer the menacing face of
Janus kinase C J Watson and K Hughes Cell Death
Differ 21 185-186 doi10.1038/cdd.2013.170 The
apoptotic pore on mitochondria are we breaking
through or still stuck? C Borner and D W
Andrews Cell Death Differ 21 187-191
doi10.1038/cdd.2013.169 PARP inhibitors and IR
join forces to strike glioblastoma-initiating
cells N Lugli, I Kamileri and T D
Halazonetis Cell Death Differ 21 192-193
doi10.1038/cdd.2013.172 Tumour-promoting role of
EMT-inducing transcription factor ZEB1 in mantle
cell lymphoma A E Sayan Cell Death Differ 21
194-195 doi10.1038/cdd.2013.178 Reviews Buildin
g blocks of the apoptotic pore how Bax and Bak
are activated and oligomerize during apoptosis
FREE D Westphal, R M Kluck and G Dewson Cell
Death Differ 21 196-205 advance online
publication, October 25, 2013 doi10.1038/cdd.201
3.139 The rheostat in the membrane BCL-2 family
proteins and apoptosis FREE N Volkmann, F M
Marassi, D D Newmeyer and D Hanein Cell Death
Differ 21 206-215 advance online publication,
October 25, 2013 doi10.1038/cdd.2013.153
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Immunobiology of mesenchymal stem cells Open S
Ma, N Xie, W Li, B Yuan, Y Shi and Y Wang Cell
Death Differ 21 216-225 advance online
publication, November 1, 2013 doi10.1038/cdd.201
3.158 Role of caspase-8 in thymus function N
Pozzesi, A Fierabracci, A M Liberati, M P
Martelli, E Ayroldi, C Riccardi and D V
Delfino Cell Death Differ 21 226-233 advance
online publication, November 22, 2013
doi10.1038/cdd.2013.166 Original
Papers Dysregulated STAT1-SOCS1 control of JAK2
promotes mammary luminal progenitor cell survival
and drives ERa tumorigenesis S R Chan, C G
Rickert, W Vermi, K C F Sheehan, C Arthur, J A
Allen, J M White, J Archambault, S Lonardi, T M
McDevitt, D Bhattacharya, M V Lorenzi, D C Allred
and R D Schreiber Cell Death Differ 21 234-246
advance online publication, September 13, 2013
doi10.1038/cdd.2013.116 The EMT activator ZEB1
promotes tumor growth and determines differential
response to chemotherapy in mantle cell
lymphoma E Sánchez-Tilló, L Fanlo, L Siles, S
Montes-Moreno, A Moros, G Chiva-Blanch, R
Estruch, A Martinez, D Colomer, B Gyorffy, G Roué
and A Postigo Cell Death Differ 21 247-257
advance online publication, September 6, 2013
doi10.1038/cdd.2013.123
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Therapeutic targeting of constitutive PARP
activation compromises stem cell phenotype and
survival of glioblastoma-initiating cells FREE M
Venere, P Hamerlik, Q Wu, R D Rasmussen, L A
Song, A Vasanji, N Tenley, W A Flavahan, A B
Hjelmeland, J Bartek and J N Rich Cell Death
Differ 21 258-269 advance online publication,
October 11, 2013 doi10.1038/cdd.2013.136 Program
med necrosis, not apoptosis, is a key mediator of
cell loss and DAMP-mediated inflammation in
dsRNA-induced retinal degeneration Y Murakami, H
Matsumoto, M Roh, A Giani, K Kataoka, Y Morizane,
M Kayama, A Thanos, S Nakatake, S Notomi, T
Hisatomi, Y Ikeda, T Ishibashi, K M Connor, J W
Miller and D G Vavvas Cell Death Differ 21
270-277 advance online publication, August 16,
2013 doi10.1038/cdd.2013.109 Perturbation of
Hoxb5 signaling in vagal and trunk neural crest
cells causes apoptosis and neurocristopathies in
mice M K M Kam, M C H Cheung, J J Zhu, W W C
Cheng, E W Y Sat, P K H Tam and V C H Lui Cell
Death Differ 21 278-289 advance online
publication, October 18, 2013 doi10.1038/cdd.201
3.142 Transcriptional fine-tuning of microRNA-223
levels directs lineage choice of human
hematopoietic progenitors L Vian, M Di Carlo, E
Pelosi, F Fazi, S Santoro, A M Cerio, A Boe, V
Rotilio, M Billi, S Racanicchi, U Testa, F
Grignani and C Nervi Cell Death Differ 21
290-301 advance online publication, October 18,
2013 doi10.1038/cdd.2013.145
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miR-661 downregulates both Mdm2 and Mdm4 to
activate p53 Y Hoffman, D R Bublik, Y Pilpel and
M Oren Cell Death Differ 21 302-309 advance
online publication, October 18, 2013
doi10.1038/cdd.2013.146 Epidermal Snail
expression drives skin cancer initiation and
progression through enhanced cytoprotection,
epidermal stem/progenitor cell expansion and
enhanced metastatic potential B De Craene, G
Denecker, P Vermassen, J Taminau, C Mauch, A
Derore, J Jonkers, E Fuchs and G Berx Cell Death
Differ 21 310-320 advance online publication,
October 25, 2013 doi10.1038/cdd.2013.148 Prolyl
isomerase Pin1 and protein kinase HIPK2 cooperate
to promote cortical neurogenesis by suppressing
Groucho/TLEHes1-mediated inhibition of neuronal
differentiation R Ciarapica, L Methot, Y Tang, R
Lo, R Dali, M Buscarlet, F Locatelli, G del Sal,
R Rota and S Stifani Cell Death Differ 21
321-332 advance online publication, November 22,
2013 doi10.1038/cdd.2013.160 Sprouty1 induces a
senescence-associated secretory phenotype by
regulating NF?B activity implications for
tumorigenesis A Macià, M Vaquero, M Gou-Fàbregas,
E Castelblanco, J M Valdivielso, C Anerillas, D
Mauricio, X Matias-Guiu, J Ribera and M
Encinas Cell Death Differ 21 333-343 advance
online publication, November 22, 2013
doi10.1038/cdd.2013.161
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Cell Death and Differentiation (2014) 21,
270277 doi10.1038/cdd.2013.109 published
online 16 August 2013 Programmed necrosis, not
apoptosis, is a key mediator of cell loss and
DAMP-mediated inflammation in dsRNA-induced
retinal degeneration Y Murakami1,2, H Matsumoto1,
M Roh1, A Giani1, K Kataoka1, Y Morizane1,
M Kayama1, A Thanos1, S Nakatake2, S Notomi2,
T Hisatomi2, Y Ikeda2, T Ishibashi2, K M Connor1,
J W Miller1 and D G Vavvas1 Abstract There is no
known treatment for the dry form of an
age-related macular degeneration (AMD). Cell
death and inflammation are important biological
processes thought to have central role in AMD.
Here we show that receptor-interacting protein
(RIP) kinase mediates necrosis and enhances
inflammation in a mouse model of retinal
degeneration induced by dsRNA, a component of
drusen in AMD. In contrast to photoreceptor-induce
d apoptosis, subretinal injection of the dsRNA
analog poly(I??C) caused necrosis of the retinal
pigment epithelium (RPE), as well as macrophage
infiltration into the outer retinas. In Rip3-/-
mice, both necrosis and inflammation were
prevented, providing substantial protection
against poly(I??C)-induced retinal degeneration.
Moreover, after poly(I??C) injection, Rip3-/-
mice displayed decreased levels of
pro-inflammatory cytokines (such as TNF-a and
IL-6) in the retina, and attenuated intravitreal
release of high-mobility group box-1 (HMGB1), a
major damage-associated molecular pattern (DAMP).
In vitro, poly(I??C)-induced necrosis were
inhibited in Rip3-deficient RPE cells, which in
turn suppressed HMGB1 release and dampened TNF-a
and IL-6 induction evoked by necrotic
supernatants. On the other hand, Rip3 deficiency
did not modulate directly TNF-a and IL-6
production after poly(I??C) stimulation in RPE
cells or macrophages. Therefore, programmed
necrosis is crucial in dsRNA-induced retinal
degeneration and may promote inflammation by
regulating the release of intracellular DAMPs,
suggesting novel therapeutic targets for diseases
such as AMD.
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Previews Concerted Effort Oscillations in
Global Gene Expression during Nematode
Development Sunil Laxman, Benjamin P. Tu, Steven
L. McKnight Back to Bases How a Nucleotide
Biosynthetic Enzyme Controls p53 Activation Anna
L. Guarnieri, Joaquín M. Espinosa Articles Nitric
Oxide Sensing in Plants Is Mediated by
Proteolytic Control of Group VII ERF
Transcription Factors Daniel J. Gibbs, Nurulhikma
Md Isa, Mahsa Movahedi, Jorge Lozano-Juste,
Guillermina M. Mendiondo, Sophie Berckhan, Nora
Marín-de la Rosa, Jorge Vicente Conde, Cristina
Sousa Correia, Simon P. Pearce, George W. Bassel,
Bulut Hamali, Prabhavathi Talloji, Daniel F.A.
Tomé, Alberto Coego, Jim Beynon, David Alabadí,
Andreas Bachmair, José León, Julie E. Gray,
Frederica L. Theodoulou, Michael J.
Holdsworth Extensive Oscillatory Gene Expression
during C. elegans Larval Development Gert-Jan
Hendriks, Dimos Gaidatzis, Florian Aeschimann,
Helge Großhans Long Noncoding RNA NEAT1-Dependent
SFPQ Relocation from Promoter Region to
Paraspeckle Mediates IL8 Expression upon Immune
Stimuli Katsutoshi Imamura, Naoto Imamachi, Gen
Akizuki, Michiko Kumakura, Atsushi Kawaguchi,
Kyosuke Nagata, Akihisa Kato, Yasushi Kawaguchi,
Hiroki Sato, Misako Yoneda, Chieko Kai, Tetsushi
Yada, Yutaka Suzuki, Toshimichi Yamada, Takeaki
Ozawa, Kiyomi Kaneki, Tsuyoshi Inoue, Mika
Kobayashi, Tatsuhiko Kodama, Youichiro Wada,
Kazuhisa Sekimizu, Nobuyoshi Akimitsu
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RIG-I Modulates Src-Mediated AKT Activation to
Restrain Leukemic Stemness Xian-Yang Li, Lin-Jia
Jiang, Lei Chen, Meng-Lei Ding, He-Zhou Guo, Wu
Zhang, Hong-Xin Zhang, Xiao-Dan Ma, Xiang-Zhen
Liu, Xiao-Dong Xi, Sai-Juan Chen, Zhu Chen, Jiang
Zhu Rad54 Functions as a Heteroduplex DNA Pump
Modulated by Its DNA Substrates and Rad51 during
D Loop Formation William Douglass Wright,
Wolf-Dietrich Heyer The Intrinsically Disordered
Sem1 Protein Functions as a Molecular Tether
during Proteasome Lid Biogenesis Robert J.
Tomko, Mark Hochstrasser Multivesicular GSK3
Sequestration upon Wnt Signaling Is Controlled by
p120-Catenin/Cadherin Interaction with
LRP5/6 Meritxell Vinyoles, Beatriz Del
Valle-Pérez, Josué Curto, Rosa Viñas-Castells,
Lorena Alba-Castellón, Antonio García de
Herreros, Mireia Duñach Nucleotide Biosynthetic
Enzyme GMP Synthase Is a TRIM21-Controlled Relay
of p53 Stabilization Ashok Reddy, Jan A. van der
Knaap, Alice G.M. Bot, Adone Mohd-Sarip, Dick
H.W. Dekkers, Mieke A. Timmermans, John W.M.
Martens, Jeroen A.A. Demmers, C. Peter
Verrijzer Early Steps in Autophagy Depend on
Direct Phosphorylation of Atg9 by the Atg1
Kinase Daniel Papinski, Martina Schuschnig,
Wolfgang Reiter, Larissa Wilhelm, Christopher A.
Barnes, Alessio Maiolica, Isabella Hansmann,
Thaddaeus Pfaffenwimmer, Monika Kijanska, Ingrid
Stoffel, Sung Sik Lee, Andrea Brezovich, Jane Hua
Lou, Benjamin E. Turk, Ruedi Aebersold, Gustav
Ammerer, Matthias Peter, Claudine Kraft Arginine
Methylation Facilitates the Recruitment of TOP3B
to Chromatin to Prevent R Loop Accumulation Yanzho
ng Yang, Kevin M. McBride, Sean Hensley, Yue Lu,
Frederic Chedin, Mark T. Bedford