??? ?????? (adhesion molecules)

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??? ??????(adhesion molecules)
?????? ???????
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? ?

• ?????????,??-?????????,??????????????????????
  ?????????????
• ???????????????????
• ??????????,???-????????
• ??????????

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??? ??????

• ???????????,?????????????????????
• ???CD??
• CD(clusterof differentiation) ???
• CD????????????,???????????????????CD??????

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??? ???????

• ???????????????
• ?????
• ?????
• ????????
• ??????
• ??????
• ??????

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• ???????(integrin family )
• ??(gt17)??(8?)??????????????????,????? ?
• ?????????????????????????????????????????
• VLA-4(a4b1) ????-4 (very later antigen-4)
  ????VCAM-1(Vascular cell adhesion molecular-1)
• LFA-1(aLb2)ICAM-1,2,3

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• ???????(selectin family )
• ??????,????????????????,??????????
• L-???????????
• P-???
• E-???

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??????????????
?? ??s ?? ??
L-selectin (CD62L) GlyCAM-1 CD34 MAdCAM-1 ???? (Homing receptor) ??????? ?????????
E-selectin (CD62e) ?????????? ???? ???????????
P-selectin (CD62P) ????Lewisx P-selectin glycoprotein ligand-1 ?????? ??? ???????????
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• ??????????( Ig super family)
• ???Ig???????,??????IgV??C????????????????????
• ????IgSF???????????
• ??????
• ??IgSF??????????,?
• CD4?CD8?CD2 ??

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Molecule Ligands Distribution
ALCAM (CD166) CD6 CD166NgCAM 35 kD protein Neurons Leukocytes
CD4 MHCHIV gp120 ThymocytesT cells
CD8 MHC ThymocytesCTLNK cells
CD44 Hyaluronin Ankyrin Fibronectin MIP1ß Osteopontin Lymphocytes Epithelial WM perivascular astrocytes Glial tumors (malignant)Metastases (CD44v splice variant)
ICAM-1 (CD54) aL ß2 LFA-1 Leukocytes Endothelial cells Dendritic cells Fibroblasts Epithelium Synovial cells Disease Lys29Met mutation Susceptibility to cerebral malaria
ICAM-2 (CD102) aL ß2 (LFA-1) Endothelial cells Lymphocytes Monocytes
ICAM-3 (CD50) aL ß2 Leukocytes
LFA-2 (CD2) LFA-3 Lymphocytes Thymocytes
LFA-3 (CD 58) LFA-2 Leukocytes Stroma Endothelial cells Astrocytoma
MHC molecules
MAdCAM-1 a4ß7 L-selectin Mucosal endothelial cells
PECAM (CD31) CD31 avß3 Leukocytes Synovial cells Endothelial cells
T-cell receptor (C-region)
VCAM-1 a4ß1 a4ß7 Satellite cellsMonocytes Synovial cells Activated endothelial cells
PMP-22 protein PMP-22 Myelin
NrCAM Ig Superfamily Neural
NCAM-1 (CD56) NCAM-1 via polysialic acid Modulated by Sialyltransferase X Polysialyltransferase Neural cells
Adhesion molecule on glia (AMOG) Glial ,Neural migration
Myelin-associated glycoprotein (MAG) MAG Myelin
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• ??????(cadherin)
• ????????????,
• ??????????????,???????????????????????????

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Well known types of Calcium dependent adhesion
molecules
Type of Cadherin What tissues? Structure Intracellular binding proteins Cytoplasmic   filaments
E-Cadherin P-Cadherin epithelial cells adhesion belts (???) catenins,   alpha actinin Actin(????)
Desmosomal Cadherin epidermis and placenta Desmosomes(??) desmoplakins I, II Plakoglobin Keratin(???) desmin (?????)
N-Cadherin nerve, muscle, lens cells adhesion belts Catenins(????), alpha actinin, vinculin actin
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????????

• ?????????????,??????????,?????????????????
• CD34???????????????????,L-?????
• ????????????(GlyCAM-1)L-??????
• P????????(PSGL-1)?????????????,E?P-?????

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• ????????
• CD44
• Agrin

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??? ??????
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• ??????????????CD4,CD8
• ?????????????
• ??????????
• ?????????
• ????????????????,????????????????????????????????
  ?????????????????????
• ????(????)???(????)

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• ??????????(

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??? CD???????????????????
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• 1. ??????
• 2. ?????????
• 3. ????????????

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(No Transcript)
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The end
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