Major Histocompatibility Complex (MHC)

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??? ????????????????

• CHAPTER VIII
• Major Histocompatibility Complex (MHC)

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? ? ? ?

• 1. MHC???
• MHC?????????
• HLA?????
• MHC??????

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(No Transcript)
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• ???????????
• 1??????????????
• 2????????????????????
• 3????????????????

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????????????
??? ???
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• ?????
• ????????,????????????
• ???????(Histocompatibility antigen)
• ?????????????????????,???????

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• ???????????(major histocompatibility antigen
  system, MHS)????????????,?????????????????,??????
  ????????
• ??????????? (minor histocompatibility antigen
  system, mHS)??????????????????

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• ??????????(major histocompatibility complex,MHC)
• ??????????????????????????????????????????????
  ?????

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• ??????????MHC??????????????,????????????????H-2??,
  ??????????????(human leucocyte antigen,
  HLA)??????????????????????

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• MHC ??????????
• MHC?? MHC???????(??)
• ??MHC HLA?????(?6Cs)
• ???????HLA??/??
• ??MHC H-2?????(?17Cs)
• ???????H-2??/??

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??? MHC??????????

• ??MHC????
• (?) H-2???????17????,1500kb
• (?)HLA??? ????6??????(6q21.31)
• ??3600kb, ??224????
• HLA?????I???? II????III????

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MHC-II
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1. I???? ??I???(Ia??) A?B?C??,??HLA-I??????(
a?)? ???I???(Ib??) E?F?G??,??? HLA-I???????????
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• 2. II????
• ??II???
• DP?DQ?DR????,??HLA-II????a?????
• ???II???
• DM, DN, DO ???????HLA-II?????????????
• ????????
• ??LMP(????????)????TAP(??????)????

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• 3. III????
• ????C2?C4?B?????????????TNF????????HSP????

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HLA???????
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???MHC I??II???
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??I??II?????HLA??

• (?)????
• 1. HLA-I???
• ??????????????????????
• ???????m ?????????????

?????????----???????,?????(???)???? ????
2-m?----???T???CD8???
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• ?2. HLA-II???
• ????????????????????
• ?????????????????????

?????????????????????????? ?????????????????????CD
????
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(?)????

• HLA-I???
• ????,??????????
• HLA-II???
• ???,?????B????????????????,???T????

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I????? II?????
???????? ??????? ??CD4?CD8 ?????? ???? ???
????
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HLA I??II????????????????
HLA???? ???? ?????? ???? ??
I? (A,B,C) ?? ????m ????? ???????? ???????????,?????CD8??,?CTL????????
II?(DR,DQ,DP) ?? ??? ?????? APC,???T?? ???????????,?????CD4??,?Th????????
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??????????

• (?)?????????? III???
• (?)??????????(??II????)
• LMP,TAP,tapasin,HLA-DM,HLA-DO
• (?)???I???
• HLA-E? HLA-G?
• (?)??????
• TNF????,????????,MHC I?????(MICA / B),HSP????

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• ??? MHC???????????
• ??????MHC???????????
• ??????????MHC?????????
• MHC-I???????8-10??????,MHC-II????13-17??????

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MHC-? ,???????????????
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??? MHC????????

• ???????????????????
• (?)MHC I I???????????????????????
• MHC I??????????????????

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MHC-II ? ? ? ? ? ? ? ? ?
? ? ?
CD4 T ??
CD4
TCR
CD28
???
MHC-II
B7
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APC
?????
2

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?,?????????
???
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???
1
MHC-II?????
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• (?)???-MHC-TCR????????????
• MHC????????????????????MHC??-????????T???????M
  HC ???- TCR?????????????????

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• (?) MHC???
• TCR??????APC????????????,?????????????????MHC?
  ?,??????MHC???(MHC restriction)?
• MHC????????????????T???APC??,??????????T??????
  ??? ?Tc-????MF-Th?Th-B????

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MHC???
??X????TCR?APC??MHC???? ???
MHC????,????? ????
????,?MHC???? ????
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• ????????????????
• ????????
• 1???????????
• 2????I????MICA??
• 3???????

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??? HLA????? ?? HLA????? ???????---HLA???????
???????HLA???????????????1??????????? HLA
???????? ?????????,?????????????,???????HLA??
??????
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HLA??????
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HLA??????
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?? HLA???????????

• 1?MHC-I????????????????MHC-I???,?????????60???
  ???MHC- I??????
• 2?MHC-II??????????????MHC-II?????,??-??????????
  ?,??????,???????T??,??I????(?????)?

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• ?? HLA?????

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• ???HLA ???????????
• ??HLA????????,?????????????????,HLA??????????????
  ???
• HLA???????????????????????,?????????????????????
  
• ?????????,???????????????????,?????????????????
  ??

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• ?????????
• ????
• DNA??HLA????????
• ????????

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???

• ????
• MHC
• MHC???
• ??
• ?????????????????HLA I??II????