Title: ??????C
1??????C
?11? ?????????
?? ?
???????????
2??? ????
3???????????
4??? ????
5???????? ????????
6???? ????
7????????
8????????
9???????
???
????????????? ????????????? ????
???
???????????? ?????????????? ?????
10???????
?????????????????? DNA???????????????? ???????????
??????? ??????????
???DNA????????????? ??????????????????? ?????????
11????
12????
??????????????????? ????????????
13??????????(?????)
??????
??
??
??
??
X
???? ????
??
??????? ????????
???? ????
???????? ??????
???
14???????????
??
?
??
??
???
???
15???????????
16???????????
???????????????? ????(????7?195-200??)
17???????????
???????????????????????? ????(????6?185-195??)
18???????????
???
????(????7?195-200??)
19???????????
????????????????????? ????????(????8?200-230??)
20???????????
????????????????????? ?????????(????11?320-440??)
21???????????
??????????????
22???????????
???????????????????? (????12?440-580??)
23???????????
24????????????
???????????????
25?????????(???)
??
??
????
???? ??
??? ????
26???????????
bicoid mRNA????????????? ????????nanos
mRNA????? ????????????
???????
??????????????????? ???????????????
27?????
???????
??????????????
????????
??????????
??????????????
??????????
28????? ???
ftz????? ????7?? ??????
?????? eve???? ???ftz ????
29???????????
???
???????? ????
30???????????
??????? ????
31Drosophila Antp 1 11 21
31 41 51 1 MTMSTNNCES
MTSYFTNSYM GADMHHGHYP GNGVTDLDAQ QMHHYSQNAN
HQGNMPYPRF 60 61 PPYDRMPYYN GQGMDQQQQH
QVYSRPDSPS SQVGGVMPQA QTNGQLGVPQ QQQQQQQQPS
120 121 QNQQQQQAQQ APQQLQQQLP QVTQQVTHPQ
QQQQQPVVYA SCKLQAAVGG LGMVPEGGSP 180 181
PLVDQMSGHH MNAQMTLPHH MGHPQAQLGY TDVGVPDVTE
VHQNHHNMGM YQQQSGVPPV 240 241 GAPPQGMMHQ
GQGPPQMHQG HPGQHTPPSQ NPNSQSSGMP SPLYPWMRSQ
FGKCQERKRG 300 301 RQTYTRYQTL ELEKEFHFNR
YLTRRRRIEI AHALCLTERQ IKIWFQNRRM KWKKENKTKG
360 361 EPGSGGEGDE ITPPNSPQ Drosophila Ubx
1 11 21 31 41
51 1 MNSYFEQASG FYGHPHQATG MAMGSGGHHD
QTASAAAAAY RGFPLSLGMS PYANHHLQRT 60 61
TQDSPYDASI TAACNKIYGD GAGAYKQDCL NIKADAVNGY
KDIWNTGGSN GGGGGGGGGG 120 121 GGGAGGTGGA
GNANGGNAAN ANGQNNPAGG MPVRPSACTP DSRVGGYLDT
SGGSPVSHRG 180 181 GSAGGNVSVS GGNGNAGGVQ
SGVGVAGAGT AWNANCTISG AAAQTAAASS LHQASNHTFY
240 241 PWMAIAGECP EDPTKSKIRS DLTQYGGIST
DMGKRYSESL AGSLLPDWLG TNGLRRRGRQ 300 301
TYTRYQTLEL EKEFHTNHYL TRRRRIEMAH ALCLTERQIK
IWFQNRRMKL KKEIQAIKEL 360 361 NEQEKQAQAQ
KAAAAAAAAA AVQGGHLDQ
32????????DNA???
33?????????????
??????????????????? ?????????
???????3?????????? ????
????????????????????
34??????????
Antp RKRGRQTYTR YQTLELEKEF HFNRYLTRRR
RIEIAHALCL TERQIKIWFQ NRRMKWKKEN Ubx
RRRGRQTYTR YQTLELEKEF HTNHYLTRRR RIEMAHALCL
TERQIKIWFQ NRRMKLKKEI Am HOX3 GKRARTAYTS
AQLVELEKEF HFNRYLCRPR RVEMAAMLNL TERQIKIWFQ
NRRMKYKKEQ ChickHOXA2 SRRLRTAYTN TQLLELEKEF
HFNKYLCRPR RVEIAALLDL TERQVKVWFQ
NRRMKHKRQT HumanHOXA1 PNAVRTNFTT KQLTELEKEF
HFNKYLTRAR RVEIAASLQL NETQVKIWFQ NRRMKQKKRE
?????????????????? ?????
HumanHOXA1 PNAVRTNFTT KQLTELEKEF HFNKYLTRAR
RVEIAASLQL NETQVKIWFQ NRRMKQKKRE MouseHOXA1
PNAVRTNFTT KQLTELEKEF HFNKYLTRAR RVEIAASLQL
NETQVKIWFQ NRRMKQKKRE XenopusHOXA1 PNTARTNFTT
KQLTELEKEF HFNKYLTRAR RVEIAAALQL NETQVKIWFQ
NRRMKQKKRE ZebrafishHOXA1 QNIIRTNFTT KQLTELEKEF
HFNKYLTRAR RVEVAATLEL NETQVKIWFQ NRRMKQKKRE
??HOXA1??????????? ????
35??????????
36?????????
???????
37?????????
??
AER?? ???? ??
?or??
38?????????
??????AER?????????? ???????????
????????????????? ??????????
?????????????????? ??????????????
39???????
?????????????????
???????????
?????????????????? ??????????
??????????????