MY GOAL:

1
Tues 03.26.13
MT 16, Human Genetics Disorders

• TOPIC
• MY GOAL
• Just
• Somethin
• to think
• about
• What
• would
• you do
• if

I will differentiate between a karyotype a
pedigree ? finish my baby

• you knew you were going to have a
• child with a genetic disorder. The
• disorder may be physical, mental or
• both..What would you do???

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POLYGENIC INHERITANCE
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Poly many, Genic genes

• When a single trait is controlled by 2 or more
  alleles
• Most human traits
• Hair color
• skin color
• eye color
• height

4
KARYOTYPE
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• KARYOTYPE
• 46 xsomes
• 44 are autosomes
• 2 are sex xsomes
• 1pr XX or XY
• egg - X or X
• sperm - X or Y

X
Sperm determines sex of the offspring
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REVIEW Karyotype- Male or female? - Normal or
abnormal?
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REVIEW - What indicates this is a male?-
Normal or abnormal? - How many PAIRS of xsomes
do we have?
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PEDIGREE
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• PEDIGREE
• Since it is unethical to use humans as test
  subjects, and it would take too long to get
  results anyway, one of the best ways to study
  human patterns of inheritance is to go back in
  time

1. Which symbol represents Males? Females?
2. Which are the oldest? Youngest?
3. How many generations?
4. What does the shaded symbol mean?
5. How many children did II-7 8 have?
6. How many children did I-1 2 have?
7. If III-1 produced a child, what is the chance she
   will produce a child who is affected?

Squares
Circles
Left
Right
III
Genetically Affected
Four
Five
50 if husband hetero 0 if he is homozygous
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Finish your baby!
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1. Study? A little bit?

HOMEWORK
Be the change you wish to see in the world