PATHOLOGY

1
? ? ?
PATHOLOGY
?????
??????
?????? ?
2
? ?
?????? ???(pathology)????????????????????
??????(etiology)?????(pathogenesis)?????(pathologi
cal change)?????????????????? ???????????????????
?????
????????? ????????????????????,????
?,?????????? ????????????????????(???
????????)----????????
3
???????????
1?????? ???(general pathology)-?????????????????
???(??)???? ???(systemic Pathology)-?????????????
???(??)?? ????????????????????????????????,???????
????
4
2????? ?????????? ??????????(????????) ??????????
????????????????????????
5
????????????
???????????? ?????(human
pathology)????,??
????????????????
?(surgical path.)????(cytology)?
?????(experimental pathology) ????????????????
??
6

????????????????
PATHOLOGY
???? (??????????) ???? ????
???? ????

• ???
• ?????
• ?????
• ???
• ????
• ????
• ????

???????????????????????? ??????????,???????????
7
(?)?????? ?? ----??????????
???----?????? ???? ----??????????????
???????????? (?)????????
?????(???????) ?????????,??????????
??? ?????????? ?????????????????????????, W
illiam Osler??????????
8
??????????
????????,?????????????,????????????,??????
??????? (?)????????????? 1?????(autopsy???)?????
?????????????????????,???????????????????????????
?????????????????????????????????,???????????????
??????????????????
9
????
10
2???????(biopsy???) ????????????????????
???? ?,????????????????,??????? ????,?????????????
?????? ?????,????????? ?????????? ??????,???????
??? ??????????????????????,???
?,?????????????? ??????????????
11
(No Transcript)
12
3????(cytology)?? ??????????????????????? ???
??????(fine needle aspiration, FNA).
13
(?)????????? 1?????(animal experiment)
????????????,?????????? ???????????,?????????????,
????,????,??????????????? ????????,??????????????
?? ???????,????,????????? 2????????(tissue and
cell culture) ???????????????????????, ??????????
?????,???????? ????,?????,?????????
14
????????????????? ??????????? 1?????(????)
???? ???? ?????????????????
???? ??????????????????
???? 2??????(??)???????????
?? ??,????,??????????? 3??????(??)
???????????? ??,???????,????,????????
15
4???????(??) ??????????? ?????,??????????????,??
???????????? 5????????????????????? ???,?????????
?????????? ???????,???????????????? ??????????????
??,?????? ????????
16
6????????? ????
??,????????????
7??????(flow cytometry, FCM)
???????DNA----??????DNA????
SG2/M????????????(????),
????????????????
??????
??????
17
8???????(image analysis) ?????????????????????? ?
??????????????????????? 9????????
??DNA????????????(ISH)???? ???(PCR)?DNA???
18
???????? ????460-370??????,Hippocrates,???
???????(?????? ???????)???????????
?
18????????????Morgagni (16821771)???????????????
????????(organ
pathology)
?
19
19????,??????Vinhow(18211902)????????????????????
?? ????????(cellular
pathology)
? ????????? ????????????????????????
???,???
?????,?????
?????,??????