5-1 ??????

1
5 ??????????
2
5-1 ??????
????? TCR ?? BCR ??????? T ?? B
?????????????????????????????????/??? T
?????,???????????????????,????? (immunological
tolerance)?
3
Antigen(??) Antigenicity (???) Immunogen(???)
Immunogenicity(????) Toleragen(???) Allergen(??
?)
4
?????????

• ??Ab??TCR???????
• ?????????
• ?????(???????,DNP)??????????
• ??????????????
• ?????????????????B??? gd-T ??????

5
???????(immunogenecity)

• ????5 kDa???????????????,?????????????????????
  T ? B ???????
• ???????(???? T ? B ????)???????
• ?????????????????,???????
• ??????????????????????????
• ??????????????????????(??????)?

6
???????????????????
1 ??? -- ?????????????????? 2
??????????????(????)
???????????????????? 3 ????
????????????????????? 4 ??????(????)
??????????????????????
7
??????????
8
???????????? ?????????????????????????,????
?????????????????????4-5?????????B????????????????
????????????????????B????????24?????????????T????,
B?????????
9
???????????
1 ??????? ?????????? ??????????
???????????????????? 2 ????
???????????? 3 ?????????
?????????????? 4 ???????
??????????????????
10
T ? B ????(epitope) ??????TCR??BCR?????????T??B?
????

• B????
• ?????????
• ???????

11
B ???? (B cell epitope) ????????????????? B
????,?????????????????????????????????????????????

12
T ???? (T Cell epitope)
Ep1
Ep2
Ep3

• ???MHC??TCR?????
• ??????????
• ???????????????
• ?????????????
• ??????MHC????

13
?????????
14
TD (T-dependent)?? ? TI
(T-independent)?? ???? (Natural) ?
???? ????(auto-, self-) ? ????(foreign)
?????
15
(No Transcript)
16
(No Transcript)
17
???(hapten)
??????????????? TCR ?????
18
??? ???DNP??????????????????OVA???DNP????,??
????(Ab2)?????????????????????DNP??B??????????
19
Interaction between TCR and homocysteine
presented by HLA-A68
TCR-a chain
TCR-b chain
Homocysteine
C
Peptide
HLA-A68
b2m
20
T ????? ????MHC/??????????????TCR???
21
T ??
???
TCRVb
???
???
MHC-IIa
APC
22
??? ?????MHC-II???TCR b ???,????T??????????
23
????
24
5-2 ????????????
1 One cell,one receptor
2 Clonal selection and expansion
3 Clonal deletion
4 Lymphoid organs
5 Antigen processing and presentation(MHC)
25
MHC???????
???????????????
???????????
?????????????????
????-- Clonal deletion
26
5-3 ???????????????????
?????????? ?????????????????????????????????
??????????????????,?????????????? ??????????APC?
??????????,???????????????
27
???????????? ??????????????,??????????????????
? ??NK????????????????(ADCC)? T
???????????????? ????????????T??????IFN-g
?IL-18??????????????,?????????????????????? ?????
?IL-1?IL-12?????,??T?????? ??????????????? ????
??????????????????57???????,????????????????????
?,??????????????????????????????????????