?PD-1?????????????????,??????????: - PowerPoint PPT Presentation
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Title:
?PD-1?????????????????,??????????:
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Title: No Slide Title Author: Jizhen Lin Last modified by: (9199801009) Created Date: 1/25/2001 6:24:23 PM Document presentation format: – PowerPoint PPT presentation
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Title: ?PD-1?????????????????,??????????:
1
?PD-1????????????
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???????(2)
???????(3)
???, ??Drexel??????,???????????,??????????,?????
???????????????????????????????????????????????
????????????????,?????????????????????????????????
?????????????,?????????????,??????????????????????
????????????????????????????,?PD-1/B7-H1?4-1BB(CD1
37)?B7-H2, B7-H3 ?B7-H4??LIGHT?,?????????????????,
??????????????????????????????????????????????????
???????????????PD-1, B7-H1?CD137????????????????,?
???????????????Nature Medicine,
Cell,Immunity????????280???????????????????,??????
??
- ?PD-1?????????????????,??????????
?????(?)????(?)?PD-1?????????????????,????????????
??IgG4??????(??)??,???????????????????????????????
?????,?????????????????????????????Biacore???PD-1?
???????????????PD-1???????(ka)?????(kd)????(KD)???
???
???????(1)
- ????????????????(??????)
- ?????????????CHO,??????(LONZA)????????????????????
GS????
??????PD-1??PD-L1?????PD-1?PD-L1??????????????????
?,????????????(????????????50??),????????????????
?????????????PD-1?PD-L1????,??????????????????????
???????????
????LONZA GS??????????????????????????????????????
?????????????????????????????2000???????,???5000??
????
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