Precocious

1
Precocious AGEing in Diabetes
Precocious AGEing Effect of Type 1 Diabetes

• Background
• T1DM increases formation of advanced glycation
  end products (AGEs)
• AGEs accumulate in tissues over time
• Tissue burden is a function of chronologic age
• AGES are implicated in the development and
  progression of diabetes complications

2
Precocious AGEing in Diabetes

• Objectives
• To examine the relationship between chronologic
  age and T1DM on skin AGEs in children
• Assess accumulated skin AGEs estimated from SIF
  405c/420c data in diabetic children versus
  non-diabetic subjects

3
Precocious AGEing in Diabetes

• Study included
• Children with T1DM (n133 mean age 13 years )
• Children with T2DM (n20 mean age 15 years)
• Healthy children (n91 mean age 10 years)
• Healthy adults (n129 mean age 40 years)
• Mean duration of T1DM was 6 years and T2DM was 4
  years
• Current and former smokers were excluded
• Skin AGEs were estimated by measuring skin
  intrinsic fluorescence (SIF)

Patients and Methods

4
Precocious AGEing in Diabetes

• Results
• When adjusted for chronologic age, SIF 420c was
  higher in children with T1DM and T2DM versus
  children without diabetes (plt0.05)
• In subjects without diabetes, SIF 420c increased
  with chronologic age
• 43 of children with T1DM and 55 with T2DM had
  SIF values comparable to adults without diabetes
• Skin AGEs were associated with HbA1c but not with
  mean blood glucose levels

5
Precocious AGEing in Diabetes
SIF 420c

6
Precocious AGEing in Diabetes
Relationship of Chronologic Age with SIF 420c
7
Precocious AGEing in Diabetes

• Conclusions
• Many children with T1DM and T2DM have estimated
  skin AGE levels comparable to those that would be
  naturally observed only in adults 20 to 40 years
  of age
• Diabetes duration of 4 to 6 years is comparable
  to about 30 years of chronologic aging
• Investigators speculated that factors
  predisposing to precocious accumulation of skin
  AGEs may predispose patients to precocious
  development of diabetes complications