FaceBase

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FaceBase

• Developing 3D Craniofacial Morphometry Data and
  Tools to Transform Dysmorphology

Richard A. Spritz, MD Ophir Klein, MD,
PhD Benedikt Hallgrimsson, PhD
http//www.easy-dna.com/printed-dna-art.html
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Overview

• What is FaceBase?
• Previous Work
• Purpose
• Our Goals
• How to Participate 3D Photos
• What will happen to the data we collect?

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What is FaceBase?

• A group of research teams around the country
  studying facial development and facial
  characteristics.
• www.facebase.org

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Previous Work ? FaceBase1

• We studied genetic data and facial shape in
  Tanzanian children

• We showed that 3D photos could distinguish
  altered facial development from normal

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Diagnostic Methods can be Improved

• Not sufficiently objective
• - Syndrome descriptions sometimes unclear
• Measurement Error
• - Manual measures are not very
• accurate or precise
• Limited Technology
• Some 2D and 3D photos
• Imprecise landmarking

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Our Goals

• Library of 3D Facial Scans
• Diagnostic Aid for Physicians and Scientists
• Quantitative Science

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How Does it Work?

• Dense Surface Modeling
• Geometric Morphometrics
• Automated facial landmarking
• Combine these analytical tools
• Apply to Clinical Practice!

Spritz et al
Storage, William. Augustus Once And For All
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What will I need to do?

• Sign up for an appointment
• Sign consent forms
• - I will go over the consent form with you
• - HIPAA, Patient Bill of Rights
• Medical Information Form
• Includes consent for data-sharing
• De-identified photos and data to be deposited in
  NIH FaceBase Hub database. May be shared to
  qualified researchers approved by NIH Data
  Access Committee.

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3D Photos How to Participate

• 4 Face views will be collected
• Tie hair back
• Sit still just like for a normal picture
• About 10-20 minutes total
• Each participant will be given an anonymous study
  number to preserve confidentiality

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What will happen tomy Photo and Data?

• We will take your 3D photo
• 2. We will analyze the 3D image
• 3. We will place anatomic landmarks on the 3D
  image
• 4. We will analyze the 3D images of patients with
  a specific known syndrome to define features
  characteristic of each syndrome
• 5. We will develop methods to distinguish among
  different syndromes

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Key Points

• FaseBase2 is a research study, and is part of a
  larger international project
• We aim to improve how we diagnose genetic
  syndromes that include atypical facial
  development
• We need participants to take 3D Photos
• Let me know if you are interested and sign up for
  an appointment!

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Thank you!

• Are there any questions?

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Study Contact Information
Name Phone Email/ Address
Richard A. Spritz, MD Anschutz Medical Campus University of Colorado, Denver TEL [phone] FAX [phone] richard.spritz_at_ucdenver.edu 12800 E. 19th Ave., Rm. 3100, MS8300 Aurora, CO 80045 USA 
Ophir Klein, MD PhD School of Dentistry University of California, San Francisco TEL [phone] FAX [phone] ophir.klein_at_ucsf.edu 513 Parnassus Avenue Box 0442 San Francisco, CA 94143-0442
Benedikt Hallgrimsson, PhD Department of Cell Biology and Anatomy University of Calgary TEL [phone] FAX [phone] bhallgri_at_ucalgary.edu Rm G503, Health Sciences Centre, 3330 Hospital Drive, NW Calgary, AB T2N 4N1
Elizabeth Beals, BS Study Coordinator University of California, San Francisco TEL [phone] CEL 925-285-5722 elizabeth.beals_at_ucsf.edu