Biomarkers

1

• Biomarkers
• of
• Wellness

2
1. Body Mass Index (BMI)

• BMI Weight (in kg) Height2 (in
  meters)
• Lbs/ inches2 x 703
• A BMI of
• lt25 desirable
• 25 29.9 overweight
• gt30 obese

3
2. Waist/Hip Ratio

• Waist/Hip Ratio
• Ideal lt.80 Woman and lt.95 Man
• Adipose Tissue is the largest endocrine gland in
  the body and produce
• Inflammatory chemicals
• Estrogen
• Cortisol

4
3. Blood Pressure Resting Pulse

• Blood Pressure
• Systolic less than or equal to 110mm-Good
• Diastolic equal to or less than 70mm-Good
• Greater than 130/85mm is Mildly Hypertensive
• Resting Pulse
• 55-60 Athlete
• 60-70 Good
• 70-80 Average
• gt80 Poor
• Medications??

5
4. Bioimpedance Analysis

• Phase angle
• Intracellular Water
• Body Fat

6
5. Sugar Biomarkers

• Fasting Glucose
• 80-100 mg/dl
• HbA1C- Glycosylated Hemoglobin
• Normal range is 4-5.9 . In poorly controlled
  diabetes, its 8.0 or above, and in well
  controlled patients it's less than 7.0
• The predictive value of HbA1C for total
  mortality was stronger than that documented for
  cholesterol concentration, body mass index and
  blood pressure.
• Khaw, K-T, et al, BMJ, 2001, Vol 322 1-6
• Fasting Insulin
• Increased insulin production causes insulin
  resistance
• Sign of Insulin Resistance with levels over 15
  uU/ml

7
6. Lipid Biomarkers

• Lipids, fractionated lipids
• Total Cholesterol-under 200
• Triglycerides-under 150, preferably under 100
• HDL-over 50 (male) and over 60 (female)
• LDL-under 130
• Trig/HDL ratio- under 2.0
• Chol/HDL ratio- under 3.0
• Inflammatory C-reactive protein

8
7. Core Flexibility

• Newtown 1st law of Physics
• An object in motion.
• Use it or
• Computerized Inclinometry and Core Flexibility
  Testing
• Increased spinal motion (proprioception)
• Decreases Sympathetic tone (stress response)
• Increases cognition (learning)
• Increases visceral function
• Increased muscle tone and posture

9
8. Posture

• Somatic Retraction, Increased Sagittal Balance,
  Anterior Weight Bearing occurs as C7 moves
  anterior to the sacral base
• Every inch of increase?10 fold increase in
  posterior cervical muscle activity (hello tight
  traps!!)
• Resistance to compression R N2 1
• Positive Sagittal Balance reduces blood flow to
  the brain and senses by 30
• All measures of health status show significantly
  poorer scores as C7 plumb line increase
• Spine 200530(18)2023-9
• Digital Postural Evaluation (posture pro)

10
9. Systems Evaluation

• Medical Symptoms Questionnaire (MSQ)
• Identifies symptoms in most body systems
• Quantifies patients level of symptoms
• Provides a simple metric to track patient
  improvement

11
10. Chiropractic Biomarkers

• X-ray
• EMG
• Thermography
• HRV
• Inclinometry
• Muscle testing
• Palpation

12
1 Biomarker of Aging

• . . . no decline with age is as dramatic or
  potentially more significant than the decline in
  lean body mass.

J Nutr 127990S-991S (1997)
13

• What Gets Measured-
• Gets Managed