Biomarkers in Alzheimers Disease, 2011

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Aarkstore.com Biomarkers in Alzheimers Disease,
2011
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Summary

• This report provides an overview of biomarkers
  associated with Alzheimers disease (AD) that
  have potential in differential diagnosis, in
  following treatment, in clinical trials and drug
  discovery. These include molecules found in CSF
  and blood, genotypes, image-based parameters and
  others. AD biomarkers offer utility in a number
  of ways identification of groups at risk of
  developing AD early detection of AD
  differentiation of different forms of
  neurodegenerative disease from AD, as well as
  developmental stages (such as MCI), thought to
  progress to AD supporting specific treatments or
  pharmacological interventions following the
  time-course progression of AD and response to
  therapy assessing patient prognosis advancing
  understanding of the disease, including risk
  factors, and the changes that precede its
  development the identification of new drug
  targets and candidate molecules development of
  discovery assays for efficacy or toxicity
  markers and supporting the recruitment of
  subjects most likely to provide a meaningful
  analysis of treatment effects. These areas are,
  therefore, considered and discussed in relation
  to the AD biomarkers presented in this report.

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Table of Contents

• Chapter 1 Background p.251. Alzheimers Disease
  1.1 Statistics and Costs 1.2 Histopathology
  1.3 Amyloid Beta (Abeta) 1.4 Tau Proteins and
  Neurofibrillary Tangles 1.5 Cholinergic
  Hypothesis 1.6 Diagnosis 1.7 Cognitive Tests
  1.8 Stages of Alzheimers Disease 1.9 Treatment
  of AD 1.10 Biomarkers 1.11 Genetics 1.12
  Autoantibodies1.13 Blood Brain Barrier1.14
  Pathogenesis of Alzheimers diseaseReferences
  (Chapter 1)

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