Role of ciproxin in

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• Role of ciproxin in
• Presented by
• Dr. ayesha inam
• Ho medical a unit

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• List of contents
• Definition Etiology
• Transmission
• Pathogenesis
• Signs and symptoms
• Investigation
• Prevention
• Treatment
• Cipro highlights
• Side effects
• contraindications

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• Typhoid fever An
  infectious feverish disease caused by the
  bacterium Salmonella and less commonly by
• Salmonella paratyphi.
• Acute generalized infection of the
• reticulo endothelial system,
• intestinal lymphoid tissue, and the gall
  bladder.

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RISK AREA

• Typhoid Fever is still common in the developing
  world. It affects about 21.5 million people
  worldwide every year.

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• Transmission
• fecal-oral route
• close contact with patients or carriers
• contaminated water and food
• flies and cockroaches.

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PATHOGENESIS
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• Signs symptoms
• First week Slowly rising temperature with
  relative ,bradycardia ,malaise headache and cough
• Second week High fever, delerium, bradycardia,
  hepatospleenomegaly, rose spots
• Third week Encephalitis, septicemia, intestinal
  haemorrhage and perforation
• Fourth week
• This carries into final fourth week.

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• Investigations
  
• Routine examination
• Bacteriogical examination
• Blood ,Urine, stool and bone
• marrow culture
• Serological examination
• Widal test

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• prevention
• Safe drinking water
• Good sanitary system
• Hand washing
• Safe disposal of feces and urine
• Vaccination

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• 
  Treatment
• General
• Sypmtomatic
• Specific
• Quinolones(first choice)
• Cephalosporin
• chloremphenicol
• In conjunction with metronidazole

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• 
  
• cipfroxin(Ciprofloxacin)
• Cipro is an broad spectrum antibiotic in a group
  of drugs called fluoroquinolones.
• Availability
• Ciprofloxacin is available as
• tablets (100 mg, 250 mg, 500 mg, 750 mg or
  1000 mg)
• intravenous solutions (5 and 10, 100 mL)

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• cipro highlights
• Most potent fluorinated quinolone
• Broad spectrum antibiotic
• Rapid bactericidal activity at low concentration
• Rapid blood and tissue distribution
• Good bioavailability
• Extended half life
• Well tolerated by all patients
• Convenient BD dose

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• Common side effects
• Diarrhea dizziness headache loss of
  appetite nausea
• serious side effects
• peripheral neuropathy ,spontaneous tendon
  rupture tendonitis ,acute liver failure or
  serious liver injury (hepatitis),phototoxicity
  reactions.Psychotic reactions acute
  pancreatitis, bone marrow depression.

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• Contraindications
• Coadministration with drugs metabolized by
  CYP1A2
• "Concomitant administration with tizanidine
• history of hypersensitivity to ciprofloxacin.
• "Local I.V. site reactions are more frequent
• pediatric population,pregnant and nursing mothers

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