Concept of Premalignancy

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Concept of Premalignancy
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• Premalignant Lesions
• vs
• Premalignant Conditions

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Leukoplakia

• Definition
• Etiology
• Incidence
• Clinical features
• Histopathology

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Leukoplakia
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Leukoplakia

• H/p
• Hyper keratinization Ortho or Para
• Acanthosis
• Dysplasia Features of Epithelial Dysplasia
• Abnormal mitosis
• Individual cell keratinization keratin pearl
• Altered nuclear cytoplasmic ratio, nucleus has
  undergone enlargement
• Nuclear Hyperchromatism
• Prominent nucleoli

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• Features of Epithelial dysplasia contd.
• Dyskaryosis Altered nucleus
• Poikilokaryosis
• Loss of polarity
• Disorientation
• Loss of Intercellular adhesion
• Drop shaped rete pegs
• Loss of Stratification

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• Malignant transformation of Leukoplakia

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Loss of StratificationLoss of cohesionProminent
NucleiPleomorphism
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Loss of stratificationMitotic figuresLoss of
PolarityPleomorphismNuclear
hyperchromatismAltered NC ratioDrop shaped
rete pegs
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Epithelial Dysplasia
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Epithelial Dysplasia